Ambient Air Pollution and Risk of Congenital Anomalies in England, 1991-99
Ambient Air Pollution and Risk of Congenital Anomalies in England, 1991-99
OBJECTIVES: To investigate whether there is an association between risk of congenital anomaly and annual ward level exposure to air pollution in England during the 1990s. METHODS: A geographical study was conducted across four regions of England with population-based congenital anomaly registers, 1991-99. Exposure was measured as 1996 annual mean background SO2, PM10 and NO2 concentrations at census ward level (n=1474). Poisson regression, controlling for maternal age, area socioeconomic deprivation, and hospital catchment area was used to estimate relative risk for an increase in pollution from the 10th to the 90th centile. RESULTS: For non-chromosomal anomalies combined, relative risks were 0.99 (95%CI 0.93-1.05) for SO2, 0.97 (95%CI 0.84-1.11) for NO2, 0.89(95%CI 0.75-1.07) for PM10. For chromosomal anomalies, relative risks were 1.06 (95%CI 0.98-1.15) for SO2, 1.11 (95%CI 0.95-1.30) for NO2, 1.18 (0.97-1.42) for PM10. Raised risks were found for Tetralogy of Fallot and SO2 (RR=1.38, 95%CI 1.07-1.79), NO2 (RR=1.44, 95%CI 0.71-2.93) and PM10 (RR=1.48, 95%CI 0.57-3.84), of interest in the light of previously reported associations between this cardiac anomaly and other air pollutants. CONCLUSIONS: While air pollution in the 1990s did not lead to sustained geographical differences in overall congenital anomaly rate in England, further research regarding specific anomalies is indicated.
223-227
Dolk, H.
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Armstrong, B.
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Lachowycz, K.
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Vrijheid, M.
1a2d6bc3-548e-422c-a10c-72caa0f6732e
Rankin, J.
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Abramsky, L.
d152009f-196f-4c84-8ab5-dad358d4e2fb
Boyd, P.
509f4035-a6d0-40e0-9a48-12836a96fee3
Wellesley, D.
17cbd6c1-0efb-4df1-ae05-64a44987c9c0
April 2010
Dolk, H.
74d140fa-b30c-4e14-9ac5-0897504bfad7
Armstrong, B.
0e5e3eb2-2ebc-45d5-8222-24d388a94876
Lachowycz, K.
64271ee8-bee6-4d7e-bf8b-71f1ba04875a
Vrijheid, M.
1a2d6bc3-548e-422c-a10c-72caa0f6732e
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20
Abramsky, L.
d152009f-196f-4c84-8ab5-dad358d4e2fb
Boyd, P.
509f4035-a6d0-40e0-9a48-12836a96fee3
Wellesley, D.
17cbd6c1-0efb-4df1-ae05-64a44987c9c0
Dolk, H., Armstrong, B., Lachowycz, K., Vrijheid, M., Rankin, J., Abramsky, L., Boyd, P. and Wellesley, D.
(2010)
Ambient Air Pollution and Risk of Congenital Anomalies in England, 1991-99.
Occupational & Environmental Medicine, 67 (4), .
(doi:10.1136/oem.2009.045997).
Abstract
OBJECTIVES: To investigate whether there is an association between risk of congenital anomaly and annual ward level exposure to air pollution in England during the 1990s. METHODS: A geographical study was conducted across four regions of England with population-based congenital anomaly registers, 1991-99. Exposure was measured as 1996 annual mean background SO2, PM10 and NO2 concentrations at census ward level (n=1474). Poisson regression, controlling for maternal age, area socioeconomic deprivation, and hospital catchment area was used to estimate relative risk for an increase in pollution from the 10th to the 90th centile. RESULTS: For non-chromosomal anomalies combined, relative risks were 0.99 (95%CI 0.93-1.05) for SO2, 0.97 (95%CI 0.84-1.11) for NO2, 0.89(95%CI 0.75-1.07) for PM10. For chromosomal anomalies, relative risks were 1.06 (95%CI 0.98-1.15) for SO2, 1.11 (95%CI 0.95-1.30) for NO2, 1.18 (0.97-1.42) for PM10. Raised risks were found for Tetralogy of Fallot and SO2 (RR=1.38, 95%CI 1.07-1.79), NO2 (RR=1.44, 95%CI 0.71-2.93) and PM10 (RR=1.48, 95%CI 0.57-3.84), of interest in the light of previously reported associations between this cardiac anomaly and other air pollutants. CONCLUSIONS: While air pollution in the 1990s did not lead to sustained geographical differences in overall congenital anomaly rate in England, further research regarding specific anomalies is indicated.
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Submitted date: January 2009
Published date: April 2010
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Local EPrints ID: 69822
URI: http://eprints.soton.ac.uk/id/eprint/69822
ISSN: 1351-0711
PURE UUID: 60ab3649-60dd-4419-a108-412cdb147ec2
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Date deposited: 08 Dec 2009
Last modified: 13 Mar 2024 19:47
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Author:
H. Dolk
Author:
B. Armstrong
Author:
K. Lachowycz
Author:
M. Vrijheid
Author:
J. Rankin
Author:
L. Abramsky
Author:
P. Boyd
Author:
D. Wellesley
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