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Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort

Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort
Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort
Background: genetic variants of the two adjacent genes, IL13 and IL4 have frequently been reported as being associated with susceptibility to atopy and asthma, both in adults and children, and some studies also suggest association with lung function and chronic obstructive pulmonary disease.
Methods: in this study, we examined for the first time the effect of these variants in 2918 adults in a longitudinal birth cohort, the British National Survey of Health and Development, where there are extensive life style, developmental and environmental data. We examine two IL13 single nucleotide polymorphisms (SNPs) IL13 rs20541 (R110Q) and rs1800925 (?1024C>T) and one IL4 SNP, rs2070874 (?33C>T) with likely function.
Results: we show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth. IL13 rs20541 does however act as a confounder for the IL13 rs1800925 associations, meaning that there is no statistical support for rs1800925 having an independent effect. There is nevertheless evidence for interaction between smoking and rs1800925, with allergy as outcome. None of the SNPs showed association with measures of lung function, nor any interaction with the effect of smoking on lung function.
Conclusion: in a longitudinal population cohort we have established a role for polymorphism of IL13 in determining susceptibility to both atopy and asthma
allergy, asthma, cohort, genetics epidemiology, hay-fever
0105-4538
1172-1178
Black, S.
32bdd48e-0bcf-456a-8e1d-b5f2804a847e
Teixeira, A.S.
37db6f9d-010b-4301-aef2-74bcdfdf197e
Loh, A.X.W.
e336de67-8344-4f71-8dde-310914892d97
Vinall, L.
aae1f8d0-3675-4492-b779-34d625e0d8f9
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Hardy, R.
b3f0f66e-4cda-4e9a-aca1-955f7ecdd132
Swallow, D.M.
cbfeaf2b-d10a-4f17-ae81-65c1160434f9
Black, S.
32bdd48e-0bcf-456a-8e1d-b5f2804a847e
Teixeira, A.S.
37db6f9d-010b-4301-aef2-74bcdfdf197e
Loh, A.X.W.
e336de67-8344-4f71-8dde-310914892d97
Vinall, L.
aae1f8d0-3675-4492-b779-34d625e0d8f9
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Hardy, R.
b3f0f66e-4cda-4e9a-aca1-955f7ecdd132
Swallow, D.M.
cbfeaf2b-d10a-4f17-ae81-65c1160434f9

Black, S., Teixeira, A.S., Loh, A.X.W., Vinall, L., Holloway, J.W., Hardy, R. and Swallow, D.M. (2009) Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort. Allergy, 64 (8), 1172-1178. (doi:10.1111/j.1398-9995.2009.01988.x).

Record type: Article

Abstract

Background: genetic variants of the two adjacent genes, IL13 and IL4 have frequently been reported as being associated with susceptibility to atopy and asthma, both in adults and children, and some studies also suggest association with lung function and chronic obstructive pulmonary disease.
Methods: in this study, we examined for the first time the effect of these variants in 2918 adults in a longitudinal birth cohort, the British National Survey of Health and Development, where there are extensive life style, developmental and environmental data. We examine two IL13 single nucleotide polymorphisms (SNPs) IL13 rs20541 (R110Q) and rs1800925 (?1024C>T) and one IL4 SNP, rs2070874 (?33C>T) with likely function.
Results: we show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth. IL13 rs20541 does however act as a confounder for the IL13 rs1800925 associations, meaning that there is no statistical support for rs1800925 having an independent effect. There is nevertheless evidence for interaction between smoking and rs1800925, with allergy as outcome. None of the SNPs showed association with measures of lung function, nor any interaction with the effect of smoking on lung function.
Conclusion: in a longitudinal population cohort we have established a role for polymorphism of IL13 in determining susceptibility to both atopy and asthma

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More information

Published date: August 2009
Keywords: allergy, asthma, cohort, genetics epidemiology, hay-fever

Identifiers

Local EPrints ID: 69841
URI: https://eprints.soton.ac.uk/id/eprint/69841
ISSN: 0105-4538
PURE UUID: 544c2ff7-0c25-4253-b0d4-80d0bdea9182
ORCID for J.W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 08 Dec 2009
Last modified: 06 Jun 2018 12:59

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