Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10?11) and MSRA (WC, P = 8.9×10?9). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10?8). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity
e1000508-[13pp]
Lindgren, C.M.
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Heid, I.M.
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Randall, J.C.
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Lamina, C.
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Steinthorsdottir, V.
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Qi, L.
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Speliotes, E.K.
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Thorleifsson, G.
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Willer, C.J.
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Herrera, B.M.
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Jackson, A.U.
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Lim, N.
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Scheet, P.
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Soranzo, N.
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Aulchenko, Y.S.
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Chambers, J.C.
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Drong, A.
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Luan, J.
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Lyon, H.N.
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Rivadeneira, F.
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Sanna, S.
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Timpson, N.J.
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Zillikens, M.C.
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Zhao, J.H.
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Almgren, P.
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Bandinelli, S.
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Bennett, A.J.
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Bergman, R.N.
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Bumpstead, S.J.
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Chanock, S.J.
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Cherkas, L.
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Chines, P.
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Coin, L.
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Cooper, C.
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Crawford, G.
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Doering, A.
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Dominiczak, A.
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Doney, A.S.
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Ebrahim, S.
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Elliott, P.
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Erdos, M.R.
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Estrada, K.
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Ferrucci, L.
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Fischer, G.
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Forouhi, N.G.
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Gieger, C.
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Grallert, H.
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Holloway, J.W.
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Wellcome Trust Case Control Consortium
June 2009
Lindgren, C.M.
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Heid, I.M.
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Randall, J.C.
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Lamina, C.
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Steinthorsdottir, V.
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Qi, L.
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Speliotes, E.K.
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Thorleifsson, G.
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Willer, C.J.
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Herrera, B.M.
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Jackson, A.U.
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Lim, N.
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Scheet, P.
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Soranzo, N.
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Amin, N.
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Aulchenko, Y.S.
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Chambers, J.C.
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Drong, A.
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Luan, J.
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Lyon, H.N.
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Rivadeneira, F.
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Sanna, S.
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Timpson, N.J.
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Zillikens, M.C.
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Zhao, J.H.
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Almgren, P.
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Bandinelli, S.
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Bennett, A.J.
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Bergman, R.N.
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Bonnycastle, L.L.
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Bumpstead, S.J.
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Chanock, S.J.
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Cherkas, L.
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Chines, P.
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Coin, L.
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Cooper, C.
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Crawford, G.
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Doering, A.
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Dominiczak, A.
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Doney, A.S.
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Ebrahim, S.
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Elliott, P.
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Erdos, M.R.
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Estrada, K.
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Ferrucci, L.
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Fischer, G.
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Forouhi, N.G.
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Gieger, C.
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Grallert, H.
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Holloway, J.W.
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