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SSX2IP: an emerging role in cancer

SSX2IP: an emerging role in cancer
SSX2IP: an emerging role in cancer
We describe the emerging role of Synovial Sarcoma X breakpoint 2 Interacting Protein (SSX2IP) in cancer and its still largely unknown function in human cells. In rodents, SSX2IP has been shown to play a role in adherens junctions and cell adhesion, while in chickens SSX2IP was identified by virtue of its regulation by the light cycle and circadian rhythms. In humans, SSX2IP was identified through its interaction with the cancer-testis gene SSX2. However SSX2IP is expressed in a range of normal and fetal tissues unlike SSX2. SSX2IP containing constructs indicated that SSX2IP could be expressed in the nucleus and cytoplasm of transfected human cells, however, SSX2IP expression has been subsequently shown to peak on the surface of myeloid leukaemia cells during mitosis. Here we discuss the current knowledge of SSX2IP function in several species and the growing evidence that SSX2IP may be a suitable target for leukaemia immunotherapy
SSX2IP, ADIP, LCG, cell cycle, immunotherapy, leukaemia associated antigens, acute myeloid leukaemia
0006-291X
462-465
Breslin, Angela
60ec9b2c-ccff-42f9-9d31-3f48acff2f2f
Denniss, Frances A.K.
7fd95e83-79e6-4b81-b8a8-c8924f36450f
Guinn, Barbara-ann
728d28c9-a23d-413a-ba1d-4531005705d7
Breslin, Angela
60ec9b2c-ccff-42f9-9d31-3f48acff2f2f
Denniss, Frances A.K.
7fd95e83-79e6-4b81-b8a8-c8924f36450f
Guinn, Barbara-ann
728d28c9-a23d-413a-ba1d-4531005705d7

Breslin, Angela, Denniss, Frances A.K. and Guinn, Barbara-ann (2007) SSX2IP: an emerging role in cancer. Biochemical and Biophysical Research Communications, 363 (3), 462-465. (doi:10.1016/j.bbrc.2007.09.052).

Record type: Article

Abstract

We describe the emerging role of Synovial Sarcoma X breakpoint 2 Interacting Protein (SSX2IP) in cancer and its still largely unknown function in human cells. In rodents, SSX2IP has been shown to play a role in adherens junctions and cell adhesion, while in chickens SSX2IP was identified by virtue of its regulation by the light cycle and circadian rhythms. In humans, SSX2IP was identified through its interaction with the cancer-testis gene SSX2. However SSX2IP is expressed in a range of normal and fetal tissues unlike SSX2. SSX2IP containing constructs indicated that SSX2IP could be expressed in the nucleus and cytoplasm of transfected human cells, however, SSX2IP expression has been subsequently shown to peak on the surface of myeloid leukaemia cells during mitosis. Here we discuss the current knowledge of SSX2IP function in several species and the growing evidence that SSX2IP may be a suitable target for leukaemia immunotherapy

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More information

Published date: 24 November 2007
Keywords: SSX2IP, ADIP, LCG, cell cycle, immunotherapy, leukaemia associated antigens, acute myeloid leukaemia

Identifiers

Local EPrints ID: 69865
URI: https://eprints.soton.ac.uk/id/eprint/69865
ISSN: 0006-291X
PURE UUID: f77ddddb-97f1-4160-97b4-d5a3a3c1a438

Catalogue record

Date deposited: 14 Dec 2009
Last modified: 19 Jul 2019 23:46

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