Standardisation of molecular monitoring for chronic myeloid leukaemia
Standardisation of molecular monitoring for chronic myeloid leukaemia
Molecular monitoring of chronic myeloid leukaemia (CML) patients by real time quantitative reverse transcriptase PCR (RQ-PCR) is of clinical value, but the use of diverse laboratory protocols and units of measurement make it difficult to compare results between and sometimes within centres. This review explores the intrinsic difficulties in standardising the RQ-PCR analysis, summarises the progress that has been made following the proposal for a new International Scale for BCR-ABL measurement and discusses how further improvements are likely to be made.
BCR-ABL, real time PCR, international scale, minimal residual disease
355-365
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
September 2009
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Cross, Nicholas C.P.
(2009)
Standardisation of molecular monitoring for chronic myeloid leukaemia.
Best Practice and Research Clinical Haematology, 22 (3), .
(doi:10.1016/j.beha.2009.04.001).
Abstract
Molecular monitoring of chronic myeloid leukaemia (CML) patients by real time quantitative reverse transcriptase PCR (RQ-PCR) is of clinical value, but the use of diverse laboratory protocols and units of measurement make it difficult to compare results between and sometimes within centres. This review explores the intrinsic difficulties in standardising the RQ-PCR analysis, summarises the progress that has been made following the proposal for a new International Scale for BCR-ABL measurement and discusses how further improvements are likely to be made.
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Published date: September 2009
Keywords:
BCR-ABL, real time PCR, international scale, minimal residual disease
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Local EPrints ID: 69866
URI: http://eprints.soton.ac.uk/id/eprint/69866
ISSN: 1521-6926
PURE UUID: 29ba1e1e-3f07-449a-8b56-b6c3ed21cd35
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Date deposited: 08 Dec 2009
Last modified: 14 Mar 2024 02:46
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