Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2
Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 times 10-23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 times 10-8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q
585-590
Ahmed, S.
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Ghoussaini, M.
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Healey, C.S.
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Humphreys, M.K.
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Platte, R.
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Morrison, J.
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Maranian, M.
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Pooley, K.A.
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Luben, R.
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Eccles, D.
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Evans, D.G.
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Fletcher, O.
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Johnson, N.
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dos Santos Silva, I.
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Peto, J.
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Stratton, M.R.
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Rahman, N.
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Jacobs, K.
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Prentice, R.
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Anderson, G.L.
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Rajkovic, A.
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Curb, J.D.
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Ziegler, R.G.
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Berg, C.D.
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Buys, S.S.
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McCarthy, C.A.
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Feigelson, H.S.
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Calle, E.E.
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Thun, M.J.
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Diver, W.R.
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Bojesen, S.
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Nordestgaard, B.G.
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Flyger, H.
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Dork, T.
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Schurmann, P.
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Hillemanns, P.
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Karstens, J.H.
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Bogdanova, N.V.
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Antonenkova, N.N.
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Zalutsky, I.V.
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Bermisheva, M.
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Fedorova, S.
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Khusnutdinova, E.
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Kang, D.
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Yoo, K.Y.
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Noh, D.Y.
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Ahn, S.H.
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Devilee, P.
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van Asperen, C.J.
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Tollenaar, R.S.
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May 2009
Ahmed, S.
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Ghoussaini, M.
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Healey, C.S.
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Humphreys, M.K.
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Platte, R.
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Morrison, J.
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Maranian, M.
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Pooley, K.A.
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Luben, R.
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Eccles, D.
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Evans, D.G.
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Fletcher, O.
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Johnson, N.
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dos Santos Silva, I.
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Peto, J.
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Stratton, M.R.
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Rahman, N.
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Jacobs, K.
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Prentice, R.
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Anderson, G.L.
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Rajkovic, A.
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Curb, J.D.
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Ziegler, R.G.
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Berg, C.D.
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Buys, S.S.
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McCarthy, C.A.
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Feigelson, H.S.
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Calle, E.E.
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Thun, M.J.
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Diver, W.R.
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Bojesen, S.
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Nordestgaard, B.G.
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Flyger, H.
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Dork, T.
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Schurmann, P.
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Hillemanns, P.
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Karstens, J.H.
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Bogdanova, N.V.
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Antonenkova, N.N.
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Zalutsky, I.V.
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Bermisheva, M.
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Fedorova, S.
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Khusnutdinova, E.
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Kang, D.
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Yoo, K.Y.
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Noh, D.Y.
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Ahn, S.H.
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Devilee, P.
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van Asperen, C.J.
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Tollenaar, R.S.
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