The University of Southampton
University of Southampton Institutional Repository

Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2

Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2
Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 times 10-23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 times 10-8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q
1061-4036
585-590
Ahmed, S.
8946ec30-34fd-4a8a-b3e9-89f326b57251
Ghoussaini, M.
1c8e7bb3-ce82-4f08-a2e8-ae1f29d9a4fd
Healey, C.S.
a267e04d-550e-44d5-b321-c23120e6ee60
Humphreys, M.K.
41ddd8bf-e257-4e36-aca2-5629c5807395
Platte, R.
6401fb23-5b0e-4c9f-8a45-100dd0f17d6d
Morrison, J.
76731e0a-4817-496e-8d9f-c69e00cf2e79
Maranian, M.
88516f12-aba7-49bd-ba1a-6ebbc05f3701
Pooley, K.A.
965a7580-d42e-4cec-81b1-9efbbd653acf
Luben, R.
bc2d12a2-27cf-4d0f-bc02-ee00b7b7b5d5
Eccles, D.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Evans, D.G.
b58c99fc-4da0-4d7e-b140-f22307befe5e
Fletcher, O.
0219ba24-dbff-4dd1-8d5d-129e83e3d3a4
Johnson, N.
257d69be-33a5-4967-bdc9-3a5e46f2ba26
dos Santos Silva, I.
42f12121-59b8-4c3f-a429-ba7f8b6a5141
Peto, J.
e6de4fa9-83fe-4cd8-8ade-00571799204d
Stratton, M.R.
e43300ce-fae0-4413-af97-185c3b34ec3d
Rahman, N.
6b59a4f8-b2c5-46a3-a660-66baab614029
Jacobs, K.
03c1ae46-c13e-4716-a8f3-5338db9b9fa4
Prentice, R.
28b30571-6525-43a2-99c0-f29e7fbc73d6
Anderson, G.L.
072a56bc-e37c-42af-b67d-2d76fd5c2eee
Rajkovic, A.
fc0d8725-5c1f-4c72-86cd-ca49b5cdcb24
Curb, J.D.
4f277d5e-373b-4d16-bbff-a4707927f8d6
Ziegler, R.G.
fcad703c-1e34-4e5d-bffb-3ff995768ca1
Berg, C.D.
8b7cc257-77fa-43c9-ac82-7478f3d479ae
Buys, S.S.
f40da36f-d07f-4a9b-b115-993a87b4425c
McCarthy, C.A.
35870438-ae78-4fe1-a626-7179f0e57091
Feigelson, H.S.
cf1703b5-9e7f-4b25-8785-e901de9a218b
Calle, E.E.
9853fc55-1773-4822-951f-cad88554ed25
Thun, M.J.
19a69e05-47f2-4303-9282-789603753552
Diver, W.R.
56668cb9-249a-4f40-841b-c27e5dbd3804
Bojesen, S.
851487bb-146b-4c2e-9ee0-ad18c3eeceb3
Nordestgaard, B.G.
9a8a1978-4cf6-4211-9193-4ab7acbf8de8
Flyger, H.
430415fc-8adf-4240-a4d1-0c20f24596b1
Dork, T.
b7ef11f1-fa10-48ae-b88b-462ea80db21d
Schurmann, P.
e204d41d-7316-41bf-922b-8ba42cee9f0c
Hillemanns, P.
3bb93995-7ae8-4352-8aaa-dbf57fad29ec
Karstens, J.H.
13910512-ed7c-431d-9161-00162e81e174
Bogdanova, N.V.
6d463aff-c68a-4ae6-a486-97a393b92332
Antonenkova, N.N.
c2ee7edc-8ae1-4af1-af5f-d23982a76666
Zalutsky, I.V.
a2930f03-b572-4a29-a1fa-7d84c7346ae1
Bermisheva, M.
fcb4678c-9945-4053-b17c-636ebd9a8a46
Fedorova, S.
10aff6cb-884c-43a9-ae89-25a09f185cba
Khusnutdinova, E.
c12244d7-a594-4ec8-91a4-8fb2e2f5f169
Kang, D.
f33e1c88-25e3-4e5d-b1db-cc9a4045af2d
Yoo, K.Y.
279a2b52-d8cf-4035-84d4-645e55336dfa
Noh, D.Y.
221b9633-ff0a-4936-8fe8-fb3166712bc4
Ahn, S.H.
bdd3ccd8-5956-4dba-a9ce-31a2c15e6bb8
Devilee, P.
ff9a4cb2-909d-4493-8116-919e285112a3
van Asperen, C.J.
68b6ac0d-fcfb-42e1-892e-7017418e4fed
Tollenaar, R.S.
e09dd145-b2b6-4d8c-bc9a-859238fdb39c
SEARCH
Ahmed, S.
8946ec30-34fd-4a8a-b3e9-89f326b57251
Ghoussaini, M.
1c8e7bb3-ce82-4f08-a2e8-ae1f29d9a4fd
Healey, C.S.
a267e04d-550e-44d5-b321-c23120e6ee60
Humphreys, M.K.
41ddd8bf-e257-4e36-aca2-5629c5807395
Platte, R.
6401fb23-5b0e-4c9f-8a45-100dd0f17d6d
Morrison, J.
76731e0a-4817-496e-8d9f-c69e00cf2e79
Maranian, M.
88516f12-aba7-49bd-ba1a-6ebbc05f3701
Pooley, K.A.
965a7580-d42e-4cec-81b1-9efbbd653acf
Luben, R.
bc2d12a2-27cf-4d0f-bc02-ee00b7b7b5d5
Eccles, D.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Evans, D.G.
b58c99fc-4da0-4d7e-b140-f22307befe5e
Fletcher, O.
0219ba24-dbff-4dd1-8d5d-129e83e3d3a4
Johnson, N.
257d69be-33a5-4967-bdc9-3a5e46f2ba26
dos Santos Silva, I.
42f12121-59b8-4c3f-a429-ba7f8b6a5141
Peto, J.
e6de4fa9-83fe-4cd8-8ade-00571799204d
Stratton, M.R.
e43300ce-fae0-4413-af97-185c3b34ec3d
Rahman, N.
6b59a4f8-b2c5-46a3-a660-66baab614029
Jacobs, K.
03c1ae46-c13e-4716-a8f3-5338db9b9fa4
Prentice, R.
28b30571-6525-43a2-99c0-f29e7fbc73d6
Anderson, G.L.
072a56bc-e37c-42af-b67d-2d76fd5c2eee
Rajkovic, A.
fc0d8725-5c1f-4c72-86cd-ca49b5cdcb24
Curb, J.D.
4f277d5e-373b-4d16-bbff-a4707927f8d6
Ziegler, R.G.
fcad703c-1e34-4e5d-bffb-3ff995768ca1
Berg, C.D.
8b7cc257-77fa-43c9-ac82-7478f3d479ae
Buys, S.S.
f40da36f-d07f-4a9b-b115-993a87b4425c
McCarthy, C.A.
35870438-ae78-4fe1-a626-7179f0e57091
Feigelson, H.S.
cf1703b5-9e7f-4b25-8785-e901de9a218b
Calle, E.E.
9853fc55-1773-4822-951f-cad88554ed25
Thun, M.J.
19a69e05-47f2-4303-9282-789603753552
Diver, W.R.
56668cb9-249a-4f40-841b-c27e5dbd3804
Bojesen, S.
851487bb-146b-4c2e-9ee0-ad18c3eeceb3
Nordestgaard, B.G.
9a8a1978-4cf6-4211-9193-4ab7acbf8de8
Flyger, H.
430415fc-8adf-4240-a4d1-0c20f24596b1
Dork, T.
b7ef11f1-fa10-48ae-b88b-462ea80db21d
Schurmann, P.
e204d41d-7316-41bf-922b-8ba42cee9f0c
Hillemanns, P.
3bb93995-7ae8-4352-8aaa-dbf57fad29ec
Karstens, J.H.
13910512-ed7c-431d-9161-00162e81e174
Bogdanova, N.V.
6d463aff-c68a-4ae6-a486-97a393b92332
Antonenkova, N.N.
c2ee7edc-8ae1-4af1-af5f-d23982a76666
Zalutsky, I.V.
a2930f03-b572-4a29-a1fa-7d84c7346ae1
Bermisheva, M.
fcb4678c-9945-4053-b17c-636ebd9a8a46
Fedorova, S.
10aff6cb-884c-43a9-ae89-25a09f185cba
Khusnutdinova, E.
c12244d7-a594-4ec8-91a4-8fb2e2f5f169
Kang, D.
f33e1c88-25e3-4e5d-b1db-cc9a4045af2d
Yoo, K.Y.
279a2b52-d8cf-4035-84d4-645e55336dfa
Noh, D.Y.
221b9633-ff0a-4936-8fe8-fb3166712bc4
Ahn, S.H.
bdd3ccd8-5956-4dba-a9ce-31a2c15e6bb8
Devilee, P.
ff9a4cb2-909d-4493-8116-919e285112a3
van Asperen, C.J.
68b6ac0d-fcfb-42e1-892e-7017418e4fed
Tollenaar, R.S.
e09dd145-b2b6-4d8c-bc9a-859238fdb39c

Ahmed, S., Ghoussaini, M., Healey, C.S., Humphreys, M.K., Platte, R., Morrison, J., Maranian, M., Pooley, K.A., Luben, R., Eccles, D., Evans, D.G., Fletcher, O., Johnson, N., dos Santos Silva, I., Peto, J., Stratton, M.R., Rahman, N., Jacobs, K., Prentice, R., Anderson, G.L., Rajkovic, A., Curb, J.D., Ziegler, R.G., Berg, C.D., Buys, S.S., McCarthy, C.A., Feigelson, H.S., Calle, E.E., Thun, M.J., Diver, W.R., Bojesen, S., Nordestgaard, B.G., Flyger, H., Dork, T., Schurmann, P., Hillemanns, P., Karstens, J.H., Bogdanova, N.V., Antonenkova, N.N., Zalutsky, I.V., Bermisheva, M., Fedorova, S., Khusnutdinova, E., Kang, D., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Devilee, P., van Asperen, C.J. and Tollenaar, R.S. , SEARCH (2009) Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2. Nature Genetics, 41 (5), 585-590. (doi:10.1038/ng.354). (PMID:19330027)

Record type: Article

Abstract

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 times 10-23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 times 10-8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q

Full text not available from this repository.

More information

Published date: May 2009
Organisations: Cancer Sciences, Clinical Trials Unit

Identifiers

Local EPrints ID: 69918
URI: https://eprints.soton.ac.uk/id/eprint/69918
ISSN: 1061-4036
PURE UUID: 5446fcae-3fd0-4c5e-b41e-0f722a5da1ab

Catalogue record

Date deposited: 10 Dec 2009
Last modified: 19 Jul 2019 23:46

Export record

Altmetrics

Contributors

Author: S. Ahmed
Author: M. Ghoussaini
Author: C.S. Healey
Author: M.K. Humphreys
Author: R. Platte
Author: J. Morrison
Author: M. Maranian
Author: K.A. Pooley
Author: R. Luben
Author: D. Eccles
Author: D.G. Evans
Author: O. Fletcher
Author: N. Johnson
Author: I. dos Santos Silva
Author: J. Peto
Author: M.R. Stratton
Author: N. Rahman
Author: K. Jacobs
Author: R. Prentice
Author: G.L. Anderson
Author: A. Rajkovic
Author: J.D. Curb
Author: R.G. Ziegler
Author: C.D. Berg
Author: S.S. Buys
Author: C.A. McCarthy
Author: H.S. Feigelson
Author: E.E. Calle
Author: M.J. Thun
Author: W.R. Diver
Author: S. Bojesen
Author: B.G. Nordestgaard
Author: H. Flyger
Author: T. Dork
Author: P. Schurmann
Author: P. Hillemanns
Author: J.H. Karstens
Author: N.V. Bogdanova
Author: N.N. Antonenkova
Author: I.V. Zalutsky
Author: M. Bermisheva
Author: S. Fedorova
Author: E. Khusnutdinova
Author: D. Kang
Author: K.Y. Yoo
Author: D.Y. Noh
Author: S.H. Ahn
Author: P. Devilee
Author: C.J. van Asperen
Author: R.S. Tollenaar

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×