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Risk reducing mastectomy: outcomes in 10 European centres

Evans, D.G.R., Baildam, A.D., Anderson, E., Brain, A., Shenton, A., Vasen, H.F.A., Eccles, D., Lucassen, A., Pichert, G., Hamed, H., Moller, P., Maehle, L., Morrison, P.J., Stoppart-Lyonnet, D., Gregory, H., Smyth, E., Niederacher, D., Nestle-Krämling, C., Campbell, J., Hopwood, P., Lalloo, F. and Howell, A. (2009) Risk reducing mastectomy: outcomes in 10 European centres Journal of Medical Genetics, 46, (4), pp. 254-258. (doi:10.1136/jmg.2008.062232).

Record type: Article


Background: increasingly women at high risk of breast cancer are opting for risk reducing surgery. The aim of this study was to assess the effectiveness of this approach in women at high risk in both carriers and non-carriers of BRCA1/2.
Methods: data from 10 European centres that offer a genetic counselling and screening service to women at risk were obtained prospectively from 1995. Breast cancer risks were estimated from life tables and a control group of women at risk who did not undergo surgery.
Results: the combined centres have data on 550 women who have undergone risk reducing mastectomy with greater than 3334 women years of follow-up. Operations were carried out on women with lifetime risks of 25–80%, with an average expected incidence rate of 1% per year. No breast cancers have occurred in this cohort in the “at risk” unaffected breast, whereas >34 would have been expected. A high rate (2–3.6%) of occult disease was identified in the at risk breast at the time of surgery.
Interpretation: we conclude that risk reducing surgery is highly effective

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Published date: April 2009


Local EPrints ID: 69920
ISSN: 0022-2593
PURE UUID: 1348fbe4-2bcc-41a9-98a5-da2eede9450a

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Date deposited: 10 Dec 2009
Last modified: 19 Jul 2017 00:05

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Author: D.G.R. Evans
Author: A.D. Baildam
Author: E. Anderson
Author: A. Brain
Author: A. Shenton
Author: H.F.A. Vasen
Author: D. Eccles
Author: A. Lucassen
Author: G. Pichert
Author: H. Hamed
Author: P. Moller
Author: L. Maehle
Author: P.J. Morrison
Author: D. Stoppart-Lyonnet
Author: H. Gregory
Author: E. Smyth
Author: D. Niederacher
Author: C. Nestle-Krämling
Author: J. Campbell
Author: P. Hopwood
Author: F. Lalloo
Author: A. Howell

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