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The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions

The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920–1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html).
0007-0920
1457-1466
Antoniou, A.C.
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Cunningham, A.P.
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Peto, J.
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Evans, D.G.
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Lalloo, F.
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Narod, S.A.
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Risch, H.A.
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Eyfjord, J.E.
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Hopper, J.L.
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Southey, M.C.
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Olsson, H.
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Johannsson, O.
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Borg, A.
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Pasini, B.
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Radice, P.
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Manoukian, S.
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Eccles, D.M.
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Tang, N.
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Olah, E.
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Anton-Culver, H.
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Warner, E.
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Lubinski, J.
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Gronwald, J.
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Gorski, B.
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Tryggvadottir, L.
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Syrjakoski, K.
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Kallioniemi, O.P.
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Eerola, H.
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Nevanlinna, H.
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Pharoah, P.D.
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Easton, D.F.
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Antoniou, A.C.
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Cunningham, A.P.
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Peto, J.
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Evans, D.G.
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Lalloo, F.
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Narod, S.A.
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Risch, H.A.
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Eyfjord, J.E.
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Hopper, J.L.
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Southey, M.C.
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Olsson, H.
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Johannsson, O.
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Borg, A.
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Pasini, B.
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Radice, P.
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Manoukian, S.
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Eccles, D.M.
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Tang, N.
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Olah, E.
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Anton-Culver, H.
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Warner, E.
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Lubinski, J.
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Gronwald, J.
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Gorski, B.
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Tryggvadottir, L.
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Syrjakoski, K.
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Kallioniemi, O.P.
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Eerola, H.
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Nevanlinna, H.
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Pharoah, P.D.
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Easton, D.F.
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Antoniou, A.C., Cunningham, A.P., Peto, J., Evans, D.G., Lalloo, F., Narod, S.A., Risch, H.A., Eyfjord, J.E., Hopper, J.L., Southey, M.C., Olsson, H., Johannsson, O., Borg, A., Pasini, B., Radice, P., Manoukian, S., Eccles, D.M., Tang, N., Olah, E., Anton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tryggvadottir, L., Syrjakoski, K., Kallioniemi, O.P., Eerola, H., Nevanlinna, H., Pharoah, P.D. and Easton, D.F. (2008) The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. British Journal of Cancer, 98 (8), 1457-1466. (doi:10.1038/sj.bjc.6604305).

Record type: Article

Abstract

Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920–1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html).

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Published date: 2008

Identifiers

Local EPrints ID: 69929
URI: https://eprints.soton.ac.uk/id/eprint/69929
ISSN: 0007-0920
PURE UUID: 8e98d42c-29eb-4f30-9652-65021940fe40

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Date deposited: 06 Jan 2010
Last modified: 19 Jul 2019 23:46

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Contributors

Author: A.C. Antoniou
Author: A.P. Cunningham
Author: J. Peto
Author: D.G. Evans
Author: F. Lalloo
Author: S.A. Narod
Author: H.A. Risch
Author: J.E. Eyfjord
Author: J.L. Hopper
Author: M.C. Southey
Author: H. Olsson
Author: O. Johannsson
Author: A. Borg
Author: B. Pasini
Author: P. Radice
Author: S. Manoukian
Author: D.M. Eccles
Author: N. Tang
Author: E. Olah
Author: H. Anton-Culver
Author: E. Warner
Author: J. Lubinski
Author: J. Gronwald
Author: B. Gorski
Author: L. Tryggvadottir
Author: K. Syrjakoski
Author: O.P. Kallioniemi
Author: H. Eerola
Author: H. Nevanlinna
Author: P.D. Pharoah
Author: D.F. Easton

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