Molecular basis of myelodysplastic/myeloproliferative neoplasms
Molecular basis of myelodysplastic/myeloproliferative neoplasms
The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues1 includes within myeloid neoplasms the category "Myelodysplastic/myeloproliferative neoplasms". According to Vardiman et al.,2 these are "clonal myeloid neoplasms that at the time of initial presentation have some clinical, laboratory or morphologic findings that support a diagnosis of myelodysplastic syndrome (MDS), and other findings more consistent with myeloproliferative neoplasm (MPN)". These disorders comprise chronic myelomonocytic leukemia (CMML),3 atypical chronic myeloid leukemia (aCML, BCR-ABL1 negative),4 juvenile myelomonocytic leukemia (JMML),5 and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN, U).6 The best characterized of these unclassifiable conditions is the provisional entity defined as refractory anemia with ringed sideroblasts (RARS) associated with marked thrombocytosis (RARS-T).7
1634-1638
Reiter, Andreas
ffa23e84-4a13-4cb5-aaf0-3fafe25dbede
Invernizzi, Rosangela
176d5438-db40-4e72-a6fd-25d70c5705c3
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Cazzola, Mario
9b0cceec-9cda-47e9-81e6-c0ecac7b7480
2009
Reiter, Andreas
ffa23e84-4a13-4cb5-aaf0-3fafe25dbede
Invernizzi, Rosangela
176d5438-db40-4e72-a6fd-25d70c5705c3
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Cazzola, Mario
9b0cceec-9cda-47e9-81e6-c0ecac7b7480
Reiter, Andreas, Invernizzi, Rosangela, Cross, Nicholas C.P. and Cazzola, Mario
(2009)
Molecular basis of myelodysplastic/myeloproliferative neoplasms.
Haematologica, 94 (12), .
(doi:10.3324/haematol.2009.014001).
Abstract
The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues1 includes within myeloid neoplasms the category "Myelodysplastic/myeloproliferative neoplasms". According to Vardiman et al.,2 these are "clonal myeloid neoplasms that at the time of initial presentation have some clinical, laboratory or morphologic findings that support a diagnosis of myelodysplastic syndrome (MDS), and other findings more consistent with myeloproliferative neoplasm (MPN)". These disorders comprise chronic myelomonocytic leukemia (CMML),3 atypical chronic myeloid leukemia (aCML, BCR-ABL1 negative),4 juvenile myelomonocytic leukemia (JMML),5 and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN, U).6 The best characterized of these unclassifiable conditions is the provisional entity defined as refractory anemia with ringed sideroblasts (RARS) associated with marked thrombocytosis (RARS-T).7
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Published date: 2009
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Local EPrints ID: 69941
URI: http://eprints.soton.ac.uk/id/eprint/69941
ISSN: 0390-6078
PURE UUID: 54b37300-a8bf-4ebf-a0bb-5e9e9500e1e7
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Date deposited: 06 Jan 2010
Last modified: 14 Mar 2024 02:46
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Author:
Andreas Reiter
Author:
Rosangela Invernizzi
Author:
Mario Cazzola
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