Molecular basis of myelodysplastic/myeloproliferative neoplasms

Reiter, Andreas, Invernizzi, Rosangela, Cross, Nicholas C.P. and Cazzola, Mario (2009) Molecular basis of myelodysplastic/myeloproliferative neoplasms. Haematologica, 94 (12), 1634-1638. (doi:10.3324/haematol.2009.014001).

Abstract

The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues1 includes within myeloid neoplasms the category "Myelodysplastic/myeloproliferative neoplasms". According to Vardiman et al.,2 these are "clonal myeloid neoplasms that at the time of initial presentation have some clinical, laboratory or morphologic findings that support a diagnosis of myelodysplastic syndrome (MDS), and other findings more consistent with myeloproliferative neoplasm (MPN)". These disorders comprise chronic myelomonocytic leukemia (CMML),3 atypical chronic myeloid leukemia (aCML, BCR-ABL1 negative),4 juvenile myelomonocytic leukemia (JMML),5 and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN, U).6 The best characterized of these unclassifiable conditions is the provisional entity defined as refractory anemia with ringed sideroblasts (RARS) associated with marked thrombocytosis (RARS-T).7

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Contributors

Author: Nicholas C.P. Cross

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