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IQ late adolescence/early adulthood, risk factors in middle age, and later cancer mortality in men: the Vietnam Experience Study

IQ late adolescence/early adulthood, risk factors in middle age, and later cancer mortality in men: the Vietnam Experience Study
IQ late adolescence/early adulthood, risk factors in middle age, and later cancer mortality in men: the Vietnam Experience Study
Objectives: (i) examine the relation, if any, of pre-morbid IQ scores at 20 years of age with the risk of later cancer mortality; and (ii) explore the role, if any, of potential mediating factors (e.g. smoking, obesity), assessed in middle age, in explaining the IQ-cancer relation. Methods: Cohort study of 14, 491 male, Vietnam-era, former US army personnel with IQ test scores at around 20 years of age (1965-71), who participated in a risk factor survey at around age 38 years of age (1985-6), who were then followed up for mortality experience for 15 years. Results: There were 176 cancer deaths during mortality surveillance. We found an inverse association of IQ with later mortality from all cancers combined (age-adjusted HRper one SD decrease in IQ; 95% confidence interval: 1.27; 1.10, 1.46) and smoking-related malignancies (1.37; 1.14, 1.64). There was some attenuation following control for mediating variables, particularly smoking and income, but the gradients generally held at conventional levels of statistical significance. Conclusions: Higher scores on pre-morbid IQ tests are associated with lower risk of later cancer morality. The strength of the relation was partially mediated by established risk factors.
1122-1126
Batty, G.D.
bf322937-2cfb-4174-b5cb-dc016f0d0b8a
Mortensen, L.H.
053a4abd-af2e-486e-8e5e-5e2dedae259c
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Shipley, M.J.
da07ad9b-1ea2-41f9-8c2a-df67edd60a70
Roberts, B.A.
b51ab478-99ec-4f21-94cf-4e9f3f3c0c8c
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60
Batty, G.D.
bf322937-2cfb-4174-b5cb-dc016f0d0b8a
Mortensen, L.H.
053a4abd-af2e-486e-8e5e-5e2dedae259c
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Shipley, M.J.
da07ad9b-1ea2-41f9-8c2a-df67edd60a70
Roberts, B.A.
b51ab478-99ec-4f21-94cf-4e9f3f3c0c8c
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60

Batty, G.D., Mortensen, L.H., Gale, C.R., Shipley, M.J., Roberts, B.A. and Deary, I.J. (2009) IQ late adolescence/early adulthood, risk factors in middle age, and later cancer mortality in men: the Vietnam Experience Study. Psycho-Oncology, 18 (10), 1122-1126. (doi:10.1002/pon.1521).

Record type: Article

Abstract

Objectives: (i) examine the relation, if any, of pre-morbid IQ scores at 20 years of age with the risk of later cancer mortality; and (ii) explore the role, if any, of potential mediating factors (e.g. smoking, obesity), assessed in middle age, in explaining the IQ-cancer relation. Methods: Cohort study of 14, 491 male, Vietnam-era, former US army personnel with IQ test scores at around 20 years of age (1965-71), who participated in a risk factor survey at around age 38 years of age (1985-6), who were then followed up for mortality experience for 15 years. Results: There were 176 cancer deaths during mortality surveillance. We found an inverse association of IQ with later mortality from all cancers combined (age-adjusted HRper one SD decrease in IQ; 95% confidence interval: 1.27; 1.10, 1.46) and smoking-related malignancies (1.37; 1.14, 1.64). There was some attenuation following control for mediating variables, particularly smoking and income, but the gradients generally held at conventional levels of statistical significance. Conclusions: Higher scores on pre-morbid IQ tests are associated with lower risk of later cancer morality. The strength of the relation was partially mediated by established risk factors.

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Published date: October 2009

Identifiers

Local EPrints ID: 69953
URI: https://eprints.soton.ac.uk/id/eprint/69953
PURE UUID: b63ccd95-adf4-40ea-89a8-66d199e88a85
ORCID for C.R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

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Date deposited: 05 Jan 2010
Last modified: 06 Feb 2019 01:37

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