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World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision

World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision
In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002, World J Biol Psychiatry 3:171), recommendations for the pharmacological treatment of anxiety disorder, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are presented. Since the publication of the first version of this guideline, a substantial number of new randomized controlled studies of anxiolytics have been published. In particular, more relapse prevention studies are now available that show sustained efficacy of anxiolytic drugs. The recommendations, developed by the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-traumatic Stress Disorders, a consensus panel of 30 international experts, are now based on 510 published randomized, placebo- or comparator-controlled clinical studies (RCTs) and 130 open studies and case reports. First-line treatments for these disorders are selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and the calcium channel modulator pregabalin. Tricyclic antidepressants (TCAs) are equally effective for some disorders, but many are less well tolerated than the SSRIs/SNRIs. In treatment-resistant cases, benzodiazepines may be used when the patient does not have a history of substance abuse disorders. Potential treatment options for patients unresponsive to standard treatments are described in this overview. Although these guidelines focus on medications, non-pharmacological were also considered. Cognitive behavioural therapy (CBT) and other variants of behaviour therapy have been sufficiently investigated in controlled studies in patients with anxiety disorders, OCD, and PTSD to support them being recommended either alone or in combination with the above medicines
post-traumatic, humans, therapy, biological psychiatry, standards, obsessive-compulsive disorder, world health, stress disorders, epidemiology, anxiety disorders, drug therapy
1562-2975
248-312
Bandelow, B.
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Zohar, J.
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Hollander, E.
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Kasper, S.
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Moller, H. J.
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Allgulander, C.
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Yuso-Gutierrez, J.
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Baldwin, D. S.
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Buenvicius, R.
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Cassano, G.
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Fineberg, N.
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Gabriels, L.
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Hindmarch, I.
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Kaiya, H.
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Klein, D. F.
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Lader, M.
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Lecrubier, Y.
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Lepine, J. P.
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Liebowitz, M. R.
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Lopez-Ibor, J. J.
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Marazziti, D.
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Miguel, E. C.
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Oh, K. S.
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Preter, M.
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Rupprecht, R.
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Sato, M.
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Starcevic, V.
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Stein, D. J.
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Van Ameringen, M.
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Vega, J.
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Bandelow, B.
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Zohar, J.
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Hollander, E.
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Kasper, S.
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Moller, H. J.
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Allgulander, C.
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Yuso-Gutierrez, J.
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Baldwin, D. S.
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Buenvicius, R.
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Cassano, G.
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Fineberg, N.
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Gabriels, L.
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Hindmarch, I.
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Kaiya, H.
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Klein, D. F.
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Lader, M.
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Lecrubier, Y.
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Lepine, J. P.
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Liebowitz, M. R.
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Lopez-Ibor, J. J.
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Marazziti, D.
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Miguel, E. C.
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Oh, K. S.
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Preter, M.
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Rupprecht, R.
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Sato, M.
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Starcevic, V.
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Stein, D. J.
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Van Ameringen, M.
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Vega, J.
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Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Moller, H. J., Allgulander, C., Yuso-Gutierrez, J., Baldwin, D. S., Buenvicius, R., Cassano, G., Fineberg, N., Gabriels, L., Hindmarch, I., Kaiya, H., Klein, D. F., Lader, M., Lecrubier, Y., Lepine, J. P., Liebowitz, M. R., Lopez-Ibor, J. J., Marazziti, D., Miguel, E. C., Oh, K. S., Preter, M., Rupprecht, R., Sato, M., Starcevic, V., Stein, D. J., Van Ameringen, M. and Vega, J. (2008) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. The World Journal of Biological Psychiatry, 9 (4), 248-312. (doi:10.1080/15622970802465807).

Record type: Article

Abstract

In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002, World J Biol Psychiatry 3:171), recommendations for the pharmacological treatment of anxiety disorder, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are presented. Since the publication of the first version of this guideline, a substantial number of new randomized controlled studies of anxiolytics have been published. In particular, more relapse prevention studies are now available that show sustained efficacy of anxiolytic drugs. The recommendations, developed by the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-traumatic Stress Disorders, a consensus panel of 30 international experts, are now based on 510 published randomized, placebo- or comparator-controlled clinical studies (RCTs) and 130 open studies and case reports. First-line treatments for these disorders are selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and the calcium channel modulator pregabalin. Tricyclic antidepressants (TCAs) are equally effective for some disorders, but many are less well tolerated than the SSRIs/SNRIs. In treatment-resistant cases, benzodiazepines may be used when the patient does not have a history of substance abuse disorders. Potential treatment options for patients unresponsive to standard treatments are described in this overview. Although these guidelines focus on medications, non-pharmacological were also considered. Cognitive behavioural therapy (CBT) and other variants of behaviour therapy have been sufficiently investigated in controlled studies in patients with anxiety disorders, OCD, and PTSD to support them being recommended either alone or in combination with the above medicines

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Published date: 2008
Keywords: post-traumatic, humans, therapy, biological psychiatry, standards, obsessive-compulsive disorder, world health, stress disorders, epidemiology, anxiety disorders, drug therapy

Identifiers

Local EPrints ID: 70085
URI: https://eprints.soton.ac.uk/id/eprint/70085
ISSN: 1562-2975
PURE UUID: da736da0-c54d-4e39-a7e2-2cbd51e17e28

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Date deposited: 21 Jan 2010
Last modified: 19 Jul 2017 00:04

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Contributors

Author: B. Bandelow
Author: J. Zohar
Author: E. Hollander
Author: S. Kasper
Author: H. J. Moller
Author: C. Allgulander
Author: J. Yuso-Gutierrez
Author: D. S. Baldwin
Author: R. Buenvicius
Author: G. Cassano
Author: N. Fineberg
Author: L. Gabriels
Author: I. Hindmarch
Author: H. Kaiya
Author: D. F. Klein
Author: M. Lader
Author: Y. Lecrubier
Author: J. P. Lepine
Author: M. R. Liebowitz
Author: J. J. Lopez-Ibor
Author: D. Marazziti
Author: E. C. Miguel
Author: K. S. Oh
Author: M. Preter
Author: R. Rupprecht
Author: M. Sato
Author: V. Starcevic
Author: D. J. Stein
Author: M. Van Ameringen
Author: J. Vega

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