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Novelty and target processing during an auditory novelty oddball: a simultaneous event-related potential and functional magnetic resonance imaging study

Novelty and target processing during an auditory novelty oddball: a simultaneous event-related potential and functional magnetic resonance imaging study
Novelty and target processing during an auditory novelty oddball: a simultaneous event-related potential and functional magnetic resonance imaging study
Recent evidence suggests that both spatiotemporally distinct and overlapping brain regions are involved in bottom-up- and top-down-driven attentional processing. However, existing studies are based on a variety of different approaches, including electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), raising the question of how EEG and fMRI findings in this field are related to each other. The present study aimed at disentangling common from specific regions underlying bottom-up novelty-processing and top-down target-processing. Simultaneous EEG and fMRI recordings were employed to investigate how fMRI-identified brain regions contribute to event-related potential (ERP) signatures of novelty- and target-processing. Fourteen subjects performed a modified novelty oddball task in which either rare tones or novel sounds served as targets in different blocks, allowing us to separate novelty-related from mere distractor-related effects. ERP signatures of novelty- and target-processing could be identified, confirming previous research based on recordings outside the scanner. fMRI analyses revealed that, despite considerable overlap of regions activated during novelty- and target-processing, bilateral superior temporal and right inferior frontal areas showed pronounced activation related to novelty-processing. fMRI-informed ERP dipole seeding was used to integrate both signals. The source modeling results further implicated temporal and inferior frontal sources in novelty-processing. Target-related fMRI activation on the other hand was confirmed in a network comprising distributed frontoparietal regions as well as bilateral caudate nucleus and cerebellum. Most regions identified by fMRI showed a contribution to target-related ERP signatures. This pattern of findings underscores the potential of simultaneous EEG/fMRI recordings for the spatiotemporal characterization of target- and novelty-processing.
novelty-processing, target-processing, simultaneous EEG/fMRI, novelty P3, P3b
869-883
Strobel, Alexander
272b7bac-eae5-4649-9a2d-51416f75275a
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Sorger, Bettina
108f1ec6-5683-4e8a-876e-2544a670ef50
Peters, Judith C.
9530f58b-85fd-4327-8d88-92cfb73f1e64
Kranczioch, Cornelia
c5d9d3fb-2b54-4ae0-85dd-fb1ae11aea4f
Hoechstetter, Karsten
d65247aa-ab9d-4a5c-a70b-381ee0de2310
Engel, Andreas K.
4c9e2742-c147-46d6-b750-bcab4b5baf34
Brocke, Burkhard
60fbd65b-62d6-4eb0-ba6f-dd2b7148ef9c
Goebel, Rainer
3d3b188d-fb96-42a7-925c-6dda7504fb04
Strobel, Alexander
272b7bac-eae5-4649-9a2d-51416f75275a
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Sorger, Bettina
108f1ec6-5683-4e8a-876e-2544a670ef50
Peters, Judith C.
9530f58b-85fd-4327-8d88-92cfb73f1e64
Kranczioch, Cornelia
c5d9d3fb-2b54-4ae0-85dd-fb1ae11aea4f
Hoechstetter, Karsten
d65247aa-ab9d-4a5c-a70b-381ee0de2310
Engel, Andreas K.
4c9e2742-c147-46d6-b750-bcab4b5baf34
Brocke, Burkhard
60fbd65b-62d6-4eb0-ba6f-dd2b7148ef9c
Goebel, Rainer
3d3b188d-fb96-42a7-925c-6dda7504fb04

Strobel, Alexander, Debener, Stefan, Sorger, Bettina, Peters, Judith C., Kranczioch, Cornelia, Hoechstetter, Karsten, Engel, Andreas K., Brocke, Burkhard and Goebel, Rainer (2008) Novelty and target processing during an auditory novelty oddball: a simultaneous event-related potential and functional magnetic resonance imaging study. NeuroImage, 40 (2), 869-883. (doi:10.1016/j.neuroimage.2007.10.065).

Record type: Article

Abstract

Recent evidence suggests that both spatiotemporally distinct and overlapping brain regions are involved in bottom-up- and top-down-driven attentional processing. However, existing studies are based on a variety of different approaches, including electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), raising the question of how EEG and fMRI findings in this field are related to each other. The present study aimed at disentangling common from specific regions underlying bottom-up novelty-processing and top-down target-processing. Simultaneous EEG and fMRI recordings were employed to investigate how fMRI-identified brain regions contribute to event-related potential (ERP) signatures of novelty- and target-processing. Fourteen subjects performed a modified novelty oddball task in which either rare tones or novel sounds served as targets in different blocks, allowing us to separate novelty-related from mere distractor-related effects. ERP signatures of novelty- and target-processing could be identified, confirming previous research based on recordings outside the scanner. fMRI analyses revealed that, despite considerable overlap of regions activated during novelty- and target-processing, bilateral superior temporal and right inferior frontal areas showed pronounced activation related to novelty-processing. fMRI-informed ERP dipole seeding was used to integrate both signals. The source modeling results further implicated temporal and inferior frontal sources in novelty-processing. Target-related fMRI activation on the other hand was confirmed in a network comprising distributed frontoparietal regions as well as bilateral caudate nucleus and cerebellum. Most regions identified by fMRI showed a contribution to target-related ERP signatures. This pattern of findings underscores the potential of simultaneous EEG/fMRI recordings for the spatiotemporal characterization of target- and novelty-processing.

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More information

Published date: 1 April 2008
Keywords: novelty-processing, target-processing, simultaneous EEG/fMRI, novelty P3, P3b

Identifiers

Local EPrints ID: 70243
URI: http://eprints.soton.ac.uk/id/eprint/70243
PURE UUID: d820f9f1-d5ec-405a-9d6d-f089970a2d45

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Date deposited: 08 Mar 2010
Last modified: 13 Mar 2024 19:59

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Contributors

Author: Alexander Strobel
Author: Stefan Debener
Author: Bettina Sorger
Author: Judith C. Peters
Author: Cornelia Kranczioch
Author: Karsten Hoechstetter
Author: Andreas K. Engel
Author: Burkhard Brocke
Author: Rainer Goebel

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