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Does IQ predict total and cardiovascular disease mortality as strongly as other risk factors? Comparison of effect estimates using the Vietnam Experience Study

Does IQ predict total and cardiovascular disease mortality as strongly as other risk factors? Comparison of effect estimates using the Vietnam Experience Study
Does IQ predict total and cardiovascular disease mortality as strongly as other risk factors? Comparison of effect estimates using the Vietnam Experience Study
OBJECTIVE: To compare the strength of the relation of two measurements of IQ and 11 established risk factors with total and cardiovascular disease (CVD) mortality. METHODS: Cohort study of 4166 US male former army personnel with data on IQ test scores (in early adulthood and middle age), a range of established risk factors and 15-year mortality surveillance. RESULTS: When CVD mortality (n = 61) was the outcome of interest, the relative index of inequality (RII: hazard ratio; 95% CI) for the most disadvantaged relative to the advantaged (in descending order of magnitude of the first six based on age-adjusted analyses) was: 6.58 (2.54 to 17.1) for family income; 5.55 (2.16 to 14.2) for total cholesterol; 5.12 (2.01 to 13.0) for body mass index; 4.70 (1.89 to 11.7) for IQ in middle age; 4.29 (1.70 to 10.8) for blood glucose and 4.08 (1.63 to 10.2) for high-density lipoprotein cholesterol (the RII for IQ in early adulthood was ranked tenth: 2.88; 1.19 to 6.97). In analyses featuring all deaths (n = 233), the RII for risk factors most strongly related to this outcome was 7.46 (4.54 to 12.3) for family income; 4.41 (2.77 to 7.03) for IQ in middle age; 4.02 (2.37 to 6.83) for smoking; 3.81 (2.35 to 6.17) for educational attainment; 3.40 (2.14 to 5.41) for pulse rate and 3.26 (2.06 to 5.15) for IQ in early adulthood. Multivariable adjustment led to marked attenuation of these relations, particularly those for IQ. CONCLUSIONS: Lower scores on measures of IQ at two time points were associated with CVD and, particularly, total mortality, at a level of magnitude greater than several other established risk factors
cholesterol, cohort, blood glucose, risk, cardiovascular-disease, risk assessment, age, cohort studies, middle age, strength, smoking, risk-factors, statistics & numerical data, educational status, military personnel, united states, mass, male, mortality, intelligence, health, cardiovascular diseases, public health, methods, blood, risk factors, body mass index, psychology, disease, intelligence tests, comparative study, adult, middle aged, glucose, humans, cardiovascular disease, epidemiology
1541-1544
Batty, G. D.
b9f925eb-88c8-4f27-8148-8929fdb84149
Shipley, M. J.
3886c6f4-a47e-4934-85df-e070a83bc133
Gale, C. R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Mortensen, L. H.
e36a4771-a796-4a99-8505-e94bae1d6a47
Deary, I. J.
14b88084-7a90-44e4-9da9-1a332b7afafb
Batty, G. D.
b9f925eb-88c8-4f27-8148-8929fdb84149
Shipley, M. J.
3886c6f4-a47e-4934-85df-e070a83bc133
Gale, C. R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Mortensen, L. H.
e36a4771-a796-4a99-8505-e94bae1d6a47
Deary, I. J.
14b88084-7a90-44e4-9da9-1a332b7afafb

Batty, G. D., Shipley, M. J., Gale, C. R., Mortensen, L. H. and Deary, I. J. (2008) Does IQ predict total and cardiovascular disease mortality as strongly as other risk factors? Comparison of effect estimates using the Vietnam Experience Study. Heart, 94 (12), 1541-1544. (doi:10.1136/hrt.2008.149567).

Record type: Article

Abstract

OBJECTIVE: To compare the strength of the relation of two measurements of IQ and 11 established risk factors with total and cardiovascular disease (CVD) mortality. METHODS: Cohort study of 4166 US male former army personnel with data on IQ test scores (in early adulthood and middle age), a range of established risk factors and 15-year mortality surveillance. RESULTS: When CVD mortality (n = 61) was the outcome of interest, the relative index of inequality (RII: hazard ratio; 95% CI) for the most disadvantaged relative to the advantaged (in descending order of magnitude of the first six based on age-adjusted analyses) was: 6.58 (2.54 to 17.1) for family income; 5.55 (2.16 to 14.2) for total cholesterol; 5.12 (2.01 to 13.0) for body mass index; 4.70 (1.89 to 11.7) for IQ in middle age; 4.29 (1.70 to 10.8) for blood glucose and 4.08 (1.63 to 10.2) for high-density lipoprotein cholesterol (the RII for IQ in early adulthood was ranked tenth: 2.88; 1.19 to 6.97). In analyses featuring all deaths (n = 233), the RII for risk factors most strongly related to this outcome was 7.46 (4.54 to 12.3) for family income; 4.41 (2.77 to 7.03) for IQ in middle age; 4.02 (2.37 to 6.83) for smoking; 3.81 (2.35 to 6.17) for educational attainment; 3.40 (2.14 to 5.41) for pulse rate and 3.26 (2.06 to 5.15) for IQ in early adulthood. Multivariable adjustment led to marked attenuation of these relations, particularly those for IQ. CONCLUSIONS: Lower scores on measures of IQ at two time points were associated with CVD and, particularly, total mortality, at a level of magnitude greater than several other established risk factors

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More information

Published date: 2008
Keywords: cholesterol, cohort, blood glucose, risk, cardiovascular-disease, risk assessment, age, cohort studies, middle age, strength, smoking, risk-factors, statistics & numerical data, educational status, military personnel, united states, mass, male, mortality, intelligence, health, cardiovascular diseases, public health, methods, blood, risk factors, body mass index, psychology, disease, intelligence tests, comparative study, adult, middle aged, glucose, humans, cardiovascular disease, epidemiology

Identifiers

Local EPrints ID: 70288
URI: https://eprints.soton.ac.uk/id/eprint/70288
PURE UUID: 4272fce4-0ce4-47fe-9ada-28fc0d252faf
ORCID for C. R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

Catalogue record

Date deposited: 16 Feb 2010
Last modified: 12 Nov 2019 02:00

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