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The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep

The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep
The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep
Undernourished late gestation fetuses display asymmetric growth restriction, suggestive of a redistribution of nutritional resources. The modification of fetal organ blood supply in response to acute hypoxia is well characterized, but it is not known whether similar responses occur in response to acute reductions in nutrition, or if such late gestation responses can be influenced by early gestation nutrition. In pregnant sheep, total nutrient requirements were restricted during the peri-implantation period (PI40, 40%; PI50, 50% of total, days 1-31) or in late gestation (L, 50% total, days 104-postmortem). Control animals were fed 100% nutrient requirements. Fetal organ blood flows were measured at baseline, and during acute fetal hypoglycaemia induced by maternal insulin infusion at 125 dGA. Baseline heart rate was increased in PI40 fetuses. During hypoglycaemia, an initial rise in fetal heart rate was followed by a slower fall. Fetal femoral artery blood flow decreased, and adrenal blood flow and femoral vascular resistance increased in all fetuses during hypoglycaemia. These changes were accompanied by increased fetal plasma adrenaline and cortisol, and reduced plasma insulin levels. The maximum femoral artery blood flow response to hypoglycaemia occurred earlier in PI50 and PI40 compared with control fetuses. The late gestation fetal cardiovascular response to acute hypoglycaemia was consistent with a redistribution of combined ventricular output away from the periphery and towards central organs. One element of the peripheral vascular response was modified by peri-implantation nutrient restriction, indicating that nutritional challenges early in gestation can have an enduring impact on cardiovascular control
insulin, cortisol, adrenaline, fetal, blood supply, reduction, nutrition, animals, sheep, plasma, blood-flow, blood, maternal, growth, heart, blood flow
0022-3751
611-624
Burrage, Deborah M.
d50aaef0-6f8c-4787-ad84-6fe2bd41f18f
Braddick, Lucy
c43b91b2-a10a-414c-a73e-ed26c62c8797
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Costello, Paula
8fc5c643-2d38-4443-975a-8704af2fa755
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Burrage, Deborah M.
d50aaef0-6f8c-4787-ad84-6fe2bd41f18f
Braddick, Lucy
c43b91b2-a10a-414c-a73e-ed26c62c8797
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Costello, Paula
8fc5c643-2d38-4443-975a-8704af2fa755
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5

Burrage, Deborah M., Braddick, Lucy, Cleal, Jane K., Costello, Paula, Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2009) The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep. The Journal of Physiology, 587 (3), 611-624. (doi:10.1113/jphysiol.2008.165944).

Record type: Article

Abstract

Undernourished late gestation fetuses display asymmetric growth restriction, suggestive of a redistribution of nutritional resources. The modification of fetal organ blood supply in response to acute hypoxia is well characterized, but it is not known whether similar responses occur in response to acute reductions in nutrition, or if such late gestation responses can be influenced by early gestation nutrition. In pregnant sheep, total nutrient requirements were restricted during the peri-implantation period (PI40, 40%; PI50, 50% of total, days 1-31) or in late gestation (L, 50% total, days 104-postmortem). Control animals were fed 100% nutrient requirements. Fetal organ blood flows were measured at baseline, and during acute fetal hypoglycaemia induced by maternal insulin infusion at 125 dGA. Baseline heart rate was increased in PI40 fetuses. During hypoglycaemia, an initial rise in fetal heart rate was followed by a slower fall. Fetal femoral artery blood flow decreased, and adrenal blood flow and femoral vascular resistance increased in all fetuses during hypoglycaemia. These changes were accompanied by increased fetal plasma adrenaline and cortisol, and reduced plasma insulin levels. The maximum femoral artery blood flow response to hypoglycaemia occurred earlier in PI50 and PI40 compared with control fetuses. The late gestation fetal cardiovascular response to acute hypoglycaemia was consistent with a redistribution of combined ventricular output away from the periphery and towards central organs. One element of the peripheral vascular response was modified by peri-implantation nutrient restriction, indicating that nutritional challenges early in gestation can have an enduring impact on cardiovascular control

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More information

Published date: February 2009
Keywords: insulin, cortisol, adrenaline, fetal, blood supply, reduction, nutrition, animals, sheep, plasma, blood-flow, blood, maternal, growth, heart, blood flow
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 70312
URI: https://eprints.soton.ac.uk/id/eprint/70312
ISSN: 0022-3751
PURE UUID: 150aa0f4-db0c-4d56-bbef-a276ca3675af
ORCID for Jane K. Cleal: ORCID iD orcid.org/0000-0001-7978-4327
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for Lucy R. Green: ORCID iD orcid.org/0000-0001-7423-9696

Catalogue record

Date deposited: 10 Feb 2010
Last modified: 29 Oct 2019 01:56

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