Caslake, Muriel J., Miles, Elizabeth A., Kofler, Bettina M., Lietz, Georg, Curtis, Peter, Armah, Christopher K., Kimber, Alan C., Grew, Jilly P., Farrell, Lesley, Stannard, Julie, Napper, Frances L., Sala-Vila, Aleix, West, Annette L., Mathers, John C., Packard, Christopher, Williams, Christine M., Calder, Philip C. and Minihane, Anne M.
Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study
American Journal of Clinical Nutrition, 88, (3), . (PMID:18779276).
Full text not available from this repository.
Background: the lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits.
Objectives: we aimed to determine the effect of moderate EPA and DHA intakes (<2 g EPA+DHA/d) on the plasma fatty acid profile, lipid and apolipoprotein concentrations, lipoprotein subclass distribution, and markers of oxidative status. We also aimed to examine the effect of age, sex, and apolipoprotein E (APOE) genotype on the observed responses.
Design: three hundred twelve adults aged 20–70 y, who were prospectively recruited according to age, sex, and APOE genotype, completed a double-blind placebo-controlled crossover study. Participants consumed control oil, 0.7 g EPA+DHA/d (0.7FO), and 1.8 g EPA+DHA/d (1.8FO) capsules in random order, each for an 8-wk intervention period, separated by 12-wk washout periods.
Results: in the group as a whole, 8% and 11% lower plasma triacylglycerol concentrations were evident after 0.7FO and 1.8FO, respectively (P < 0.001): significant sex x treatment (P = 0.038) and sex x genotype x treatment (P = 0.032) interactions were observed, and the greatest triacylglycerol-lowering responses (reductions of 15% and 23% after 0.7FO and 1.8FO, respectively) were evident in APOE4 men. Furthermore, lower VLDL-cholesterol (P = 0.026) and higher LDL-cholesterol (P = 0.010), HDL-cholesterol (P < 0.001), and HDL2 (P < 0.001) concentrations were evident after fish-oil intervention.
Conclusions: supplements providing EPA+DHA at doses as low as 0.7 g/d have a significant effect on the plasma lipid profile. The results of the current trial, which used a prospective recruitment approach to examine the responses in population subgroups, are indicative of a greater triacylglycerol-lowering action of long-chain n–3 polyunsaturated fatty acids in males than in females
||great britain, docosahexaenoic acid, eicosapentaenoic acid, sex characteristics, female, nonesterified, fish oil, diet, fish-oil, aged, humans, middle aged, acid, fatty acids, administration & dosage, apolipoprotein-e, fatty acid, reduction, blood, united-kingdom, chemistry, apolipoproteins, fish oils, trial, male, biological markers, capsules, lipoproteins, adult, double-blind, plasma, analysis, oils, genotype
||02 Feb 2010
||18 Apr 2017 21:07
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