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Bend those knees!

Bend those knees!
Bend those knees!
Our evolutionary success as vertebrates has been in large part due to the development and positioning of the synovial joint, sitting as it does between our long bones, to enable us to move smoothly. Synovial fluid, the visco-elastic material filling the joint cavity, serves not only as a lubricant and a shock absorber but is also an important source of nutrients for the joint cartilage (Fam et al. 2007). One of the major components of synovial fluid and central to its rheological and other properties is the glycosaminoglycan, hyaluronic acid (HA). HA, composed of repeated disaccharide units of N-acetylglucosamine and d-glucuronic acid, has an average molecular mass of 1 × 106 Da. Its concentration in human synovial fluid is between 2 and 4 mg ml?1.
0022-3751
p.1462
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494

Clough, Geraldine (2008) Bend those knees! Journal of Physiology, 586 (6), p.1462. (doi:10.1113/jphysiol.2008.151464).

Record type: Article

Abstract

Our evolutionary success as vertebrates has been in large part due to the development and positioning of the synovial joint, sitting as it does between our long bones, to enable us to move smoothly. Synovial fluid, the visco-elastic material filling the joint cavity, serves not only as a lubricant and a shock absorber but is also an important source of nutrients for the joint cartilage (Fam et al. 2007). One of the major components of synovial fluid and central to its rheological and other properties is the glycosaminoglycan, hyaluronic acid (HA). HA, composed of repeated disaccharide units of N-acetylglucosamine and d-glucuronic acid, has an average molecular mass of 1 × 106 Da. Its concentration in human synovial fluid is between 2 and 4 mg ml?1.

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More information

Published date: 1 March 2008
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 70335
URI: http://eprints.soton.ac.uk/id/eprint/70335
DOI: doi:10.1113/jphysiol.2008.151464
ISSN: 0022-3751
PURE UUID: aaa9d82c-11c5-43e9-87fb-4c7dd31c5b1b
ORCID for Geraldine Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 05 Mar 2010
Last modified: 14 Mar 2024 02:40

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Author: Geraldine Clough ORCID iD

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