The University of Southampton
University of Southampton Institutional Repository

Update on the treatment of post-menopausal osteoporosis

Cole, Zoe, Dennison, Elaine and Cooper, Cyrus (2008) Update on the treatment of post-menopausal osteoporosis British Medical Bulletin, 86, (1), pp. 129-143. (doi:10.1093/bmb/ldn017). (PMID:18477578).

Record type: Article


Background: Osteoporosis has a huge impact on public health, through the increased morbidity, mortality and economic costs associated with resultant fractures. The goal is to evaluate and identify those that are at risk of osteoporotic fracture in order to start preventative and therapeutic measures to reduce their risk of fracture.

Sources of data: This article reviews the data from randomized controlled trials for the current therapeutic agents available in the UK. It also reviews new trial data for promising osteoporosis therapies, in particular Denosumab, a monoclonal antibody against RANK ligand.

Areas of agreement: Bisphosphonates are the current recommended first-line treatments for patients with osteoporosis.

Areas of controversy/growing points: There are a number of patients where bisphosphonates are contraindicated. Under these circumstances, it is important that clinicians have access to alternative treatments. The long-awaited National Institute for Health and Clinical Excellence (NICE) technology appraisals for both primary and secondary prevention and the clinical guidelines will clarify this. Treatment decisions should be based on risk factors and pharmaceutical intervention given to those with the highest risks.

Areas timely for developing research: Future studies are required to look at these agents in combination to see whether anti-fracture efficacy can be improved

Full text not available from this repository.

More information

Published date: June 2008
Keywords: health, osteoporosis, review, risk factors, mortality, bone, randomized controlled trials, risk, fractures, nosp, public health, therapy


Local EPrints ID: 70338
ISSN: 0007-1420
PURE UUID: 45b6f671-58a7-4bec-9a2c-517eff4d6dee
ORCID for Cyrus Cooper: ORCID iD

Catalogue record

Date deposited: 09 Mar 2010
Last modified: 19 Jul 2017 00:04

Export record


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.