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A potential mechanism for impaired vasorelaxation in a dietary model of metabolic syndrome

A potential mechanism for impaired vasorelaxation in a dietary model of metabolic syndrome
A potential mechanism for impaired vasorelaxation in a dietary model of metabolic syndrome
Poor early growth confers an increased risk of developing type 2 diabetes, hypertension, and other features of the metabolic syndrome in later life. This may result from a mismatch during early life exerting permanent effects on the structure and function of key metabolic organ systems, including the vasculature. Mice (C57BL/J) were exposed to either a high fat (HF, 45% kcal fat) or standard animal chow (C, 21% kcal fat) diet throughout pregnancy and lactation. Male offspring were then continued on the same diet as their dams or crossed over onto the alternative diet, for 10 to 12 weeks post weaning. Those fed the HF diet post weaning (HF/HF and C/HF groups) gained more weight and had a higher blood pressure than the C/C and HF/C animals. They also showed an impaired endothelium-dependent relaxation to ACh and higher basal NO production (P<0.05). Our preliminary data demonstrate the impact of an in utero and postnatal HF diet on vascular function through an impairment of NO production and/or bioavailability. It further suggests that both predisposition to disease, acquired in early life, and later lifestyle may contribute to the development of cardiovascular disease which are sustained into adulthood.
syndrome
1018-1172
167
Ethirajan, P.
03abb65f-fe37-481f-a003-d8de536bff9e
Torrens, C.
15a35713-0651-4249-8227-5901e2cfcd22
Bruce, K.
8b4b96d4-1535-4f7d-b0c0-21d4c00cceaa
Cagampang, F.
7cf57d52-4a65-4554-8306-ed65226bc50e
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Ethirajan, P.
03abb65f-fe37-481f-a003-d8de536bff9e
Torrens, C.
15a35713-0651-4249-8227-5901e2cfcd22
Bruce, K.
8b4b96d4-1535-4f7d-b0c0-21d4c00cceaa
Cagampang, F.
7cf57d52-4a65-4554-8306-ed65226bc50e
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494

Ethirajan, P., Torrens, C., Bruce, K., Cagampang, F., Hanson, M.A., Byrne, C.D. and Clough, G.F. (2008) A potential mechanism for impaired vasorelaxation in a dietary model of metabolic syndrome. Journal of Vascular Research, 45 (Supplement 2), 167. (doi:10.1159/000144991).

Record type: Article

Abstract

Poor early growth confers an increased risk of developing type 2 diabetes, hypertension, and other features of the metabolic syndrome in later life. This may result from a mismatch during early life exerting permanent effects on the structure and function of key metabolic organ systems, including the vasculature. Mice (C57BL/J) were exposed to either a high fat (HF, 45% kcal fat) or standard animal chow (C, 21% kcal fat) diet throughout pregnancy and lactation. Male offspring were then continued on the same diet as their dams or crossed over onto the alternative diet, for 10 to 12 weeks post weaning. Those fed the HF diet post weaning (HF/HF and C/HF groups) gained more weight and had a higher blood pressure than the C/C and HF/C animals. They also showed an impaired endothelium-dependent relaxation to ACh and higher basal NO production (P<0.05). Our preliminary data demonstrate the impact of an in utero and postnatal HF diet on vascular function through an impairment of NO production and/or bioavailability. It further suggests that both predisposition to disease, acquired in early life, and later lifestyle may contribute to the development of cardiovascular disease which are sustained into adulthood.

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More information

Published date: 26 August 2008
Additional Information: 25th Conference of the European Society for Microcirculation
Keywords: syndrome

Identifiers

Local EPrints ID: 70380
URI: http://eprints.soton.ac.uk/id/eprint/70380
ISSN: 1018-1172
PURE UUID: 12c8c57f-ede0-4d3f-a07b-5b7fd07b8441
ORCID for F. Cagampang: ORCID iD orcid.org/0000-0003-4404-9853
ORCID for M.A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753
ORCID for G.F. Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 16 Feb 2010
Last modified: 14 Mar 2024 02:47

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Contributors

Author: P. Ethirajan
Author: C. Torrens
Author: K. Bruce
Author: F. Cagampang ORCID iD
Author: M.A. Hanson ORCID iD
Author: C.D. Byrne ORCID iD
Author: G.F. Clough ORCID iD

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