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Adult metabolic syndrome abd impaired glucose tolerance are associated with different patterns of BMI from the New Delhi birth cohort

Adult metabolic syndrome abd impaired glucose tolerance are associated with different patterns of BMI from the New Delhi birth cohort
Adult metabolic syndrome abd impaired glucose tolerance are associated with different patterns of BMI from the New Delhi birth cohort
Objective: the purpose of this study was to describe patterns of infant, childhood, and adolescent BMI and weight associated with adult metabolic risk factors for cardiovascular disease.

Research design and methods: we measured waist circumference, blood pressure, glucose, insulin and lipid concentrations, and the prevalence of metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III definition) in 1,492 men and women aged 26–32 years in Delhi, India, whose weight and height were recorded every 6 months throughout infancy (0–2 years), childhood (2–11 years), and adolescence (11 years–adult).

Results: men and women with metabolic syndrome (29% overall), any of its component features, or higher (greater than upper quartile) insulin resistance (homeostasis model assessment) had more rapid BMI or weight gain than the rest of the cohort throughout infancy, childhood, and adolescence. Glucose intolerance (impaired glucose tolerance or diabetes) was, like metabolic syndrome, associated with rapid BMI gain in childhood and adolescence but with lower BMI in infancy.

Conclusion: in this Indian population, patterns of infant BMI and weight gain differed for individuals who developed metabolic syndrome (rapid gain) compared with those who developed glucose intolerance (low infant BMI). Rapid BMI gain during childhood and adolescence was a risk factor for both disorders.
glucose, adult, childhood, infant, insulin, women, india, insulin-resistance, cardiovascular-disease, aged, weight gain, insulin resistance, birth cohort, blood, height, patterns, syndrome, blood-pressure, prevalence, birth, homeostasis, education, diabetes, disease, glucose-tolerance, weight, cholesterol, men, cardiovascular disease, epidemiology, cohort, tolerance, infancy, adolescent, methods, risk-factors, risk factors, blood pressure, glucose intolerance, risk
1935-5548
2349-2356
Fall, Caroline H. D.
7171a105-34f5-4131-89d7-1aa639893b18
Sachdev, Harshpal Singh
2fca6c24-2750-47b4-b675-7c7da6e5c987
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Lakshmy, Ramakrishnan
7d4935a2-21b5-4d6b-8a4d-b35a02140927
Biswas, Sushant Dey
7ab8e358-b61b-42a2-86b7-967ab9848181
Prabhakaran, Dorairaj
e994435e-230b-454a-9f31-32b12aff0cc3
Tandon, Nikhil
f7cedb7c-5459-496a-9cab-27e6c236ec5b
Ramji, Siddharth
163c69b8-26a2-43e5-b676-eae78548b47f
Reddy, K. Srinath
55fb2ce8-bf9c-47bd-b329-af40739b2131
Barker, David J. P.
84efdf7a-7c52-45fc-aa16-9647f3743c27
Bhargava, Santosh K.
3932b4c9-c07d-472c-b54d-622306357475
Fall, Caroline H. D.
7171a105-34f5-4131-89d7-1aa639893b18
Sachdev, Harshpal Singh
2fca6c24-2750-47b4-b675-7c7da6e5c987
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Lakshmy, Ramakrishnan
7d4935a2-21b5-4d6b-8a4d-b35a02140927
Biswas, Sushant Dey
7ab8e358-b61b-42a2-86b7-967ab9848181
Prabhakaran, Dorairaj
e994435e-230b-454a-9f31-32b12aff0cc3
Tandon, Nikhil
f7cedb7c-5459-496a-9cab-27e6c236ec5b
Ramji, Siddharth
163c69b8-26a2-43e5-b676-eae78548b47f
Reddy, K. Srinath
55fb2ce8-bf9c-47bd-b329-af40739b2131
Barker, David J. P.
84efdf7a-7c52-45fc-aa16-9647f3743c27
Bhargava, Santosh K.
3932b4c9-c07d-472c-b54d-622306357475

Fall, Caroline H. D., Sachdev, Harshpal Singh, Osmond, Clive, Lakshmy, Ramakrishnan, Biswas, Sushant Dey, Prabhakaran, Dorairaj, Tandon, Nikhil, Ramji, Siddharth, Reddy, K. Srinath, Barker, David J. P. and Bhargava, Santosh K. (2008) Adult metabolic syndrome abd impaired glucose tolerance are associated with different patterns of BMI from the New Delhi birth cohort. Diabetes Care, 31 (12), 2349-2356. (doi:10.2337/dc08-0911). (PMID:18835958)

Record type: Article

Abstract

Objective: the purpose of this study was to describe patterns of infant, childhood, and adolescent BMI and weight associated with adult metabolic risk factors for cardiovascular disease.

Research design and methods: we measured waist circumference, blood pressure, glucose, insulin and lipid concentrations, and the prevalence of metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III definition) in 1,492 men and women aged 26–32 years in Delhi, India, whose weight and height were recorded every 6 months throughout infancy (0–2 years), childhood (2–11 years), and adolescence (11 years–adult).

Results: men and women with metabolic syndrome (29% overall), any of its component features, or higher (greater than upper quartile) insulin resistance (homeostasis model assessment) had more rapid BMI or weight gain than the rest of the cohort throughout infancy, childhood, and adolescence. Glucose intolerance (impaired glucose tolerance or diabetes) was, like metabolic syndrome, associated with rapid BMI gain in childhood and adolescence but with lower BMI in infancy.

Conclusion: in this Indian population, patterns of infant BMI and weight gain differed for individuals who developed metabolic syndrome (rapid gain) compared with those who developed glucose intolerance (low infant BMI). Rapid BMI gain during childhood and adolescence was a risk factor for both disorders.

Full text not available from this repository.

More information

Published date: December 2008
Keywords: glucose, adult, childhood, infant, insulin, women, india, insulin-resistance, cardiovascular-disease, aged, weight gain, insulin resistance, birth cohort, blood, height, patterns, syndrome, blood-pressure, prevalence, birth, homeostasis, education, diabetes, disease, glucose-tolerance, weight, cholesterol, men, cardiovascular disease, epidemiology, cohort, tolerance, infancy, adolescent, methods, risk-factors, risk factors, blood pressure, glucose intolerance, risk
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 70383
URI: https://eprints.soton.ac.uk/id/eprint/70383
ISSN: 1935-5548
PURE UUID: d2945827-ead5-4de6-921c-57381cbde7d5
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 02 Feb 2010
Last modified: 03 Dec 2019 02:00

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Contributors

Author: Harshpal Singh Sachdev
Author: Clive Osmond ORCID iD
Author: Ramakrishnan Lakshmy
Author: Sushant Dey Biswas
Author: Dorairaj Prabhakaran
Author: Nikhil Tandon
Author: Siddharth Ramji
Author: K. Srinath Reddy
Author: David J. P. Barker
Author: Santosh K. Bhargava

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