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Decreased microvascular funtional vasodilatory reserve and features of the metabolic syndrome

Decreased microvascular funtional vasodilatory reserve and features of the metabolic syndrome
Decreased microvascular funtional vasodilatory reserve and features of the metabolic syndrome
We have investigated insulin-induced changes in microvascular conductance in individuals with features of the metabolic syndrome using laser Doppler fluximetry (LDF) and a novel 785 nm, 20 mW, 4 mm separation probe (Moor Instruments Ltd, UK). 33 volunteers [52±9 y (mean ±SD); 15 men)] were studied. All gave written informed consent. LDF was measured above the anterior tibialis muscle of the non-dominant lower limb and insulin sensitivity by hyperinsulinaemic euglycaemic clamp. Measurements were made at rest and during reactive hyperaemia (RH) to arterial occlusion, before and during the clamp. Vascular conductance (VC) calculated as LDF/MABP (arbitrary units), at baseline and during RH, decreased with >3 features of the metabolic syndrome (p=0.01) and calculated overall CVD risk (p=0.01). VC at was significantly increased by insulin at baseline (0.8±0.4 vs 1.1±0.6, p=0.001) but reduced during peak RH (before insulin: 413±32 vs high dose insulin: 363±35 %baseline, p=0.01). The impaired RH response (peak VC and rate of recovery from peak) was associated with plasma total cholesterol (r2=0.51, p=0.01) and LDL cholesterol concentrations (r2=0.49, p=0.05). We conclude that individuals with features of the metabolic syndrome show a reduced functional vasodilatory reserve and that this impaired response contributes to a reduced insulin sensitivity and glucose handling by muscle.
syndrome
0892-6638
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
L'Esperance, Veline
0d44b963-1287-432c-9913-b106064551ce
Turzyniecka, Magdalena
8368c46e-6803-4750-b56c-518ea1fbf871
Krentz, Andrew
bda5225f-44be-441d-827a-c85c20070cc0
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
L'Esperance, Veline
0d44b963-1287-432c-9913-b106064551ce
Turzyniecka, Magdalena
8368c46e-6803-4750-b56c-518ea1fbf871
Krentz, Andrew
bda5225f-44be-441d-827a-c85c20070cc0
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Clough, Geraldine F., L'Esperance, Veline, Turzyniecka, Magdalena, Krentz, Andrew and Byrne, Christopher D. (2008) Decreased microvascular funtional vasodilatory reserve and features of the metabolic syndrome. The FASEB Journal, 22, supplement 1141.18.

Record type: Article

Abstract

We have investigated insulin-induced changes in microvascular conductance in individuals with features of the metabolic syndrome using laser Doppler fluximetry (LDF) and a novel 785 nm, 20 mW, 4 mm separation probe (Moor Instruments Ltd, UK). 33 volunteers [52±9 y (mean ±SD); 15 men)] were studied. All gave written informed consent. LDF was measured above the anterior tibialis muscle of the non-dominant lower limb and insulin sensitivity by hyperinsulinaemic euglycaemic clamp. Measurements were made at rest and during reactive hyperaemia (RH) to arterial occlusion, before and during the clamp. Vascular conductance (VC) calculated as LDF/MABP (arbitrary units), at baseline and during RH, decreased with >3 features of the metabolic syndrome (p=0.01) and calculated overall CVD risk (p=0.01). VC at was significantly increased by insulin at baseline (0.8±0.4 vs 1.1±0.6, p=0.001) but reduced during peak RH (before insulin: 413±32 vs high dose insulin: 363±35 %baseline, p=0.01). The impaired RH response (peak VC and rate of recovery from peak) was associated with plasma total cholesterol (r2=0.51, p=0.01) and LDL cholesterol concentrations (r2=0.49, p=0.05). We conclude that individuals with features of the metabolic syndrome show a reduced functional vasodilatory reserve and that this impaired response contributes to a reduced insulin sensitivity and glucose handling by muscle.

Full text not available from this repository.

More information

Published date: 2008
Additional Information: Meeting abstract supplement
Keywords: syndrome
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 70454
URI: https://eprints.soton.ac.uk/id/eprint/70454
ISSN: 0892-6638
PURE UUID: d3aa4b1b-a315-4276-9bd8-e4b3244786dd
ORCID for Geraldine F. Clough: ORCID iD orcid.org/0000-0002-6226-8964
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 10 Feb 2010
Last modified: 06 Jun 2018 13:02

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