A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndrome
A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndrome
We describe an unusual case of a 48-year-old white woman diagnosed with positive antihistidyl-trna synthetase antibody polymyositis (PM) shortly after suffering from life-threatening acute respiratory distress syndrome (ARDS). In view of the fact that evaluation for infectious or noninfectious etiologies of ARDS was unrevealing, we reasoned that systemic inflammation in early sub clinical PM may have precipitated alveolar-capillary membrane injury. One year after onset, PM has been maintained in remission with oral prednisone and azathioprine. This is the first report of a patient in whom ARDS was the presenting feature of anti-Jo-1 positive PM
dermatomyositis, injuries, polymyositis, report, anti-jo-1 antibody, england, etiology, inflammation, lung-disease, acute respiratory distress syndrome, syndrome
219-221
Polosa, Riccardo
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Di Mauro, C.
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Spampinato, B.
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Castelli, L.
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D'Amico, G.
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Edwards, C. J.
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Russo, C.
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2008
Polosa, Riccardo
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Di Mauro, C.
b4b7d73a-d377-4da2-8991-e28dcacf572e
Spampinato, B.
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Castelli, L.
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D'Amico, G.
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Edwards, C. J.
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Russo, C.
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Polosa, Riccardo, Di Mauro, C., Spampinato, B., Castelli, L., D'Amico, G., Edwards, C. J. and Russo, C.
(2008)
A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndrome.
JCR: Journal of Clinical Rheumatology, 14 (4), .
(doi:10.1097/RHU.0b013e31817de0d4).
Abstract
We describe an unusual case of a 48-year-old white woman diagnosed with positive antihistidyl-trna synthetase antibody polymyositis (PM) shortly after suffering from life-threatening acute respiratory distress syndrome (ARDS). In view of the fact that evaluation for infectious or noninfectious etiologies of ARDS was unrevealing, we reasoned that systemic inflammation in early sub clinical PM may have precipitated alveolar-capillary membrane injury. One year after onset, PM has been maintained in remission with oral prednisone and azathioprine. This is the first report of a patient in whom ARDS was the presenting feature of anti-Jo-1 positive PM
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Published date: 2008
Keywords:
dermatomyositis, injuries, polymyositis, report, anti-jo-1 antibody, england, etiology, inflammation, lung-disease, acute respiratory distress syndrome, syndrome
Identifiers
Local EPrints ID: 70510
URI: http://eprints.soton.ac.uk/id/eprint/70510
ISSN: 1076-1608
PURE UUID: 2b4941ec-d62a-474e-a812-a7376510d7be
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Date deposited: 12 Feb 2010
Last modified: 13 Mar 2024 20:04
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Author:
Riccardo Polosa
Author:
C. Di Mauro
Author:
B. Spampinato
Author:
L. Castelli
Author:
G. D'Amico
Author:
C. Russo
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