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The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people

The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people
The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people
Background: a number of studies have shown strong graded positive relationships between size at birth, grip strength, and estimates of muscle mass in older people. However no studies to date have included direct measures of muscle size.

Methods: we studied 313 men and 318 women born in Hertfordshire, United Kingdom between 1931 and 1939 who were still resident there and had historical records of growth in early life. Information on lifestyle was collected. and participants underwent peripheral quantitative computed tomography to directly measure forearm and calf muscle size.

Results: birth weight was positively related to forearm muscle area in the men (r = 0.24. p < .0001) and women (r = 0.17, p = .003). There were similar but weaker associations between birth weight and calf muscle area in the men (r = 0.13, p = .03) and in the women (r = 0.17, p = .004). These relationships were all attenuated by adjustment for adult size.

Conclusion: we present first evidence that directly measured muscle size in older men and women is associated with size at birth. This may reflect tracking of muscle size and is important because it suggests that benefit may be gained from taking a life course approach both to understanding the etiology of sarcopenia and to developing effective interventions
size, united-kingdom, england, birth weight, adult, low-birth-weight, birth-weight, skeletal-muscle, association, women, growth, strength, in-utero, aging, adult body-composition, etiology, grip strength, early-life, sarcopenia, hertfordshire, methods, mass, development, developmental origins, hertfordshire cohort, life, undernutrition, birth, weight, muscle
1079-5006
835-840
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Jameson, Karen
d5fb142d-06af-456e-9016-17497f94e9f2
Martin, Helen J.
147af305-a2fb-4ed5-a1fb-5453af49cb60
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Jameson, Karen
d5fb142d-06af-456e-9016-17497f94e9f2
Martin, Helen J.
147af305-a2fb-4ed5-a1fb-5453af49cb60
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Aihie Sayer, Avan, Dennison, Elaine M., Syddall, Holly E., Jameson, Karen, Martin, Helen J. and Cooper, Cyrus (2008) The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 63 (8), 835-840. (PMID:18772471)

Record type: Article

Abstract

Background: a number of studies have shown strong graded positive relationships between size at birth, grip strength, and estimates of muscle mass in older people. However no studies to date have included direct measures of muscle size.

Methods: we studied 313 men and 318 women born in Hertfordshire, United Kingdom between 1931 and 1939 who were still resident there and had historical records of growth in early life. Information on lifestyle was collected. and participants underwent peripheral quantitative computed tomography to directly measure forearm and calf muscle size.

Results: birth weight was positively related to forearm muscle area in the men (r = 0.24. p < .0001) and women (r = 0.17, p = .003). There were similar but weaker associations between birth weight and calf muscle area in the men (r = 0.13, p = .03) and in the women (r = 0.17, p = .004). These relationships were all attenuated by adjustment for adult size.

Conclusion: we present first evidence that directly measured muscle size in older men and women is associated with size at birth. This may reflect tracking of muscle size and is important because it suggests that benefit may be gained from taking a life course approach both to understanding the etiology of sarcopenia and to developing effective interventions

Full text not available from this repository.

More information

Published date: 2008
Keywords: size, united-kingdom, england, birth weight, adult, low-birth-weight, birth-weight, skeletal-muscle, association, women, growth, strength, in-utero, aging, adult body-composition, etiology, grip strength, early-life, sarcopenia, hertfordshire, methods, mass, development, developmental origins, hertfordshire cohort, life, undernutrition, birth, weight, muscle

Identifiers

Local EPrints ID: 70527
URI: https://eprints.soton.ac.uk/id/eprint/70527
ISSN: 1079-5006
PURE UUID: 4afea8cf-c769-4bfd-b878-3902ac0b33cf
ORCID for Elaine M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Holly E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 03 Feb 2010
Last modified: 10 Jan 2019 01:37

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