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Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trial

Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trial
Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trial
Background: previous investigations suggest continuous tube feeding (TF) schedules do not suppress appetite and food intake, but bolus TF has been little studied. OBJECTIVE: We tested the hypothesis that 1) bolus TF does not suppress appetite and food intake and 2) there is no interrelation between food intake and appetite mediators (including ghrelin).

Design: a single-blind, placebo-controlled trial within which 6 healthy men [body mass index (in kg/m(2)): 21.1 +/- 1.61] received 3 d of bolus TF (6.93 +/- 0.38 MJ/d of 4.18 kJ/mL multinutrient feed). For 2 d before and after TF, placebo boluses (<0.4 MJ/d) were given by tube. Hourly tracking of appetite, weighed measurements of daily ad libitum food intake, and metabolic and hormonal (including ghrelin) measurements were undertaken.

Results: total energy intake was significantly increased with bolus TF (18.2 +/- 1.86 MJ; P = 0.0005) despite a partial reduction in food intake compared with placebo periods (P = 0.013) and during the TF period (by 15%; P = 0.007). There was little change in hunger and fullness with bolus TF, and within-day temporal patterns did not differ whether TF or placebo was given. Changes in fasting concentrations of ghrelin (1003.6-756.0 pmol/L; P = 0.013) and other mediators (including leptin, insulin, and glucose) were significantly related to subsequent daily food intake (eg, ghrelin: r(2) = 0.81, P = 0.022).

Conclusions: in this short-term study, subjects maintained appetite ratings during bolus TF by a significant reduction in food intake and changes in ghrelin and some appetite mediators related to subsequent daily food intake. Longer-term studies are required to fully ascertain the effect of TF on appetite, food intake, and appetite mediators
glucose, insulin, hypothesis, fasting, methods, drug administration schedule, healthy-men, placebos, energy intake, leptin, cross-over studies, research, physiology, drug effects, reduction, questionnaires, energy metabolism, adult, trial, placebo-controlled trial, humans, intubation, indirect, enteral nutrition, calorimetry, satiety response, eating, analysis of variance, human, ghrelin, oxygen consumption, nutrition, gastrointestinal, patterns, single-blind method, appetite, time factors, united-kingdom, male, mass, men, food, blood
0002-9165
77-83
Stratton, Rebecca J.
c6a5ead1-3387-42e7-8bea-5ac7d969d87b
Stubbs, R. James
e683bc6e-07ac-4808-b721-6dfe4c8112cf
Elia, Marinos
964bf436-e623-46d6-bc3f-5dd04c9ef4c1
Stratton, Rebecca J.
c6a5ead1-3387-42e7-8bea-5ac7d969d87b
Stubbs, R. James
e683bc6e-07ac-4808-b721-6dfe4c8112cf
Elia, Marinos
964bf436-e623-46d6-bc3f-5dd04c9ef4c1

Stratton, Rebecca J., Stubbs, R. James and Elia, Marinos (2008) Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trial. American Journal of Clinical Nutrition, 88 (1), 77-83. (PMID:18614727)

Record type: Article

Abstract

Background: previous investigations suggest continuous tube feeding (TF) schedules do not suppress appetite and food intake, but bolus TF has been little studied. OBJECTIVE: We tested the hypothesis that 1) bolus TF does not suppress appetite and food intake and 2) there is no interrelation between food intake and appetite mediators (including ghrelin).

Design: a single-blind, placebo-controlled trial within which 6 healthy men [body mass index (in kg/m(2)): 21.1 +/- 1.61] received 3 d of bolus TF (6.93 +/- 0.38 MJ/d of 4.18 kJ/mL multinutrient feed). For 2 d before and after TF, placebo boluses (<0.4 MJ/d) were given by tube. Hourly tracking of appetite, weighed measurements of daily ad libitum food intake, and metabolic and hormonal (including ghrelin) measurements were undertaken.

Results: total energy intake was significantly increased with bolus TF (18.2 +/- 1.86 MJ; P = 0.0005) despite a partial reduction in food intake compared with placebo periods (P = 0.013) and during the TF period (by 15%; P = 0.007). There was little change in hunger and fullness with bolus TF, and within-day temporal patterns did not differ whether TF or placebo was given. Changes in fasting concentrations of ghrelin (1003.6-756.0 pmol/L; P = 0.013) and other mediators (including leptin, insulin, and glucose) were significantly related to subsequent daily food intake (eg, ghrelin: r(2) = 0.81, P = 0.022).

Conclusions: in this short-term study, subjects maintained appetite ratings during bolus TF by a significant reduction in food intake and changes in ghrelin and some appetite mediators related to subsequent daily food intake. Longer-term studies are required to fully ascertain the effect of TF on appetite, food intake, and appetite mediators

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Published date: July 2008
Keywords: glucose, insulin, hypothesis, fasting, methods, drug administration schedule, healthy-men, placebos, energy intake, leptin, cross-over studies, research, physiology, drug effects, reduction, questionnaires, energy metabolism, adult, trial, placebo-controlled trial, humans, intubation, indirect, enteral nutrition, calorimetry, satiety response, eating, analysis of variance, human, ghrelin, oxygen consumption, nutrition, gastrointestinal, patterns, single-blind method, appetite, time factors, united-kingdom, male, mass, men, food, blood
Organisations: Faculty of Medicine, Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 70550
URI: http://eprints.soton.ac.uk/id/eprint/70550
ISSN: 0002-9165
PURE UUID: 9a119a08-5fea-47f1-a913-99eea3338414

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Date deposited: 10 Feb 2010
Last modified: 21 Oct 2019 19:40

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