Anti-leukotrienes in asthma and allergic rhinitis.
Anti-leukotrienes in asthma and allergic rhinitis.
Leukotrienes are lipid mediators synthesized from arachidonic acid liberated from the membranes of activated inflammatory cells [1]. The subfamily of cysteinyl-leukotrienes (cys-LTs) represented by LTC4, LTD4 and LTE4 are the first inflammatory mediators to have a proven role in the pathophysiology of asthma [2] and which mimic many of the features of allergic rhinitis [3]. Antileukotriene drugs that block the synthesis of leukotrienes or antagonize cys-LT receptors have been licensed for asthma therapy in most countries in the last dozen years [4], with some of these drugs also being registered for use in allergic rhinitis [2]. This chapter will outline the sources and actions of cys-LTs in allergic airway inflammation and the clinical evidence underlying the use of antileukotriene drugs in asthma and allergic rhinitis.
asthma
978-4-431-99361-2
63-90
Sampson, Anthony Peter
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60
13 January 2010
Sampson, Anthony Peter
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60
Sampson, Anthony Peter
(2010)
Anti-leukotrienes in asthma and allergic rhinitis.
In,
Pawankar, R., Holgate, S.T. and Rosenwasser, L.
(eds.)
Allergy Frontiers: Therapy and Prevention.
(Allergy Frontiers, 5)
Tokyo, Japan.
Springer Japan, .
(doi:10.1007/978-4-431-99362-9_5).
Record type:
Book Section
Abstract
Leukotrienes are lipid mediators synthesized from arachidonic acid liberated from the membranes of activated inflammatory cells [1]. The subfamily of cysteinyl-leukotrienes (cys-LTs) represented by LTC4, LTD4 and LTE4 are the first inflammatory mediators to have a proven role in the pathophysiology of asthma [2] and which mimic many of the features of allergic rhinitis [3]. Antileukotriene drugs that block the synthesis of leukotrienes or antagonize cys-LT receptors have been licensed for asthma therapy in most countries in the last dozen years [4], with some of these drugs also being registered for use in allergic rhinitis [2]. This chapter will outline the sources and actions of cys-LTs in allergic airway inflammation and the clinical evidence underlying the use of antileukotriene drugs in asthma and allergic rhinitis.
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Published date: 13 January 2010
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ISBNs for print and online copies respectively.
Keywords:
asthma
Identifiers
Local EPrints ID: 70864
URI: http://eprints.soton.ac.uk/id/eprint/70864
ISBN: 978-4-431-99361-2
PURE UUID: b82afb8b-b251-4ca4-a80d-6c383492853d
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Date deposited: 11 Dec 2009
Last modified: 14 Mar 2024 02:39
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Contributors
Editor:
R. Pawankar
Editor:
S.T. Holgate
Editor:
L. Rosenwasser
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