Optical and impedance detection of DNA hybridisation on barcoded micro particles in a microfluidic device

Holmes, D., Whitton, A., Cavalli-Petraglia, G., Galitonov, G., Birtwell, S., Banu, S., Zheludev, N. and Morgan, H. (2006) Optical and impedance detection of DNA hybridisation on barcoded micro particles in a microfluidic device. Nano Science and Technology Institute Nanotech - Conference on Nano Electronics & Photonics, Boston, United States. 06 - 10 May 2006.

Abstract

A common problem with high throughput combinatorial chemistry is the inability to easily analyse and track the multitude of molecules produced. This bottleneck is a major problem for the big pharmaceutical companies and other researchers working in the fields of drug screening, DNA analysis, etc. To this end we have developed a microfluidic device capable of rapidly analysing the optical and impedance properties of individual polymer beads. Such beads are commonly used as solid supports for combi-chem and DNA synthesis. We have further developed the system by the use of barcoded microparticles. Each bead is uniquely identifiable by its optical diffraction pattern and can be tracked within the device allowing correlation between this unique code (which can be associated with its chemical history) and the optical and impedance measurements performed in the system.

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Contributors

Author: N. Zheludev

Author: H. Morgan

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