Serum profiling reveals distinctive proteomic markers in the serum from chronic myeloid leukaemia patients

Mohamedali, Azim, Guinn, Barbara-ann, Sahu, Satyajit, Thomas, N.S. and Mufti, Ghulam J. (2009) Serum profiling reveals distinctive proteomic markers in the serum from chronic myeloid leukaemia patients. British Journal of Haematology, 144 (2), 263-265. (doi:10.1111/j.1365-2141.2008.07434.x).

Abstract

We have shown that proteomic profiling of sera from chronic myeloid leukaemia patients at presentation identifies five serum markers whose expression profile is significantly different from that seen in normal controls, non-malignant neutrophilia and in CML patients in HR following treatment with Gleevec. Of particular interest is the persistence of three of the five biomarkers following successful induction of HR, suggesting that those changes are disease specific. We have demonstrated that serum profiling can robustly identify disease groups and disease state in patients with CML compared with non-malignant and normal controls. In addition our data suggest that serum profiling of other haematological malignancies may provide new biomarkers for disease state and stage

This record has no associated files available for download.

Contributors

Download statistics