SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients
SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients
We show that SSX2IP is affected in two ways which relate to the cell cycling of AML cells. In patients harbouring the t(15;17) translocation overexpression of SSX2IP is associated with an abnormal elevation in the expression of genes involved in cell cycle. Conversely in AML cells harbouring the t(8;21) translocation, the low levels of SSX2IP are associated with low levels of CDC20 protein, part of the anaphase-promoting complex which is thought to contribute to the development of aneuploidy seen in these patients
AML, tumour antigens, cell cycle, chromosomal rearrangements, myeloid leukaemia antigens, tumour biology
250-251
Guinn, Barbara-ann
728d28c9-a23d-413a-ba1d-4531005705d7
Bullinger, Lars
5a395588-dc36-4850-bd2c-5f66a0ca643b
Thomas, N. Shaun B.
547f56a5-1799-4ed1-b0f1-3e7d20e68850
Mills, Ken I.
be9c4b93-fda3-40b1-8514-9191652ab8b7
Greiner, Jochen
8c8d50c3-bf3a-4913-8d80-ef8d4e5d2cd8
January 2008
Guinn, Barbara-ann
728d28c9-a23d-413a-ba1d-4531005705d7
Bullinger, Lars
5a395588-dc36-4850-bd2c-5f66a0ca643b
Thomas, N. Shaun B.
547f56a5-1799-4ed1-b0f1-3e7d20e68850
Mills, Ken I.
be9c4b93-fda3-40b1-8514-9191652ab8b7
Greiner, Jochen
8c8d50c3-bf3a-4913-8d80-ef8d4e5d2cd8
Guinn, Barbara-ann, Bullinger, Lars, Thomas, N. Shaun B., Mills, Ken I. and Greiner, Jochen
(2008)
SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients.
British Journal of Haematology, 140 (2), .
(doi:10.1111/j.1365-2141.2007.06892.x).
Abstract
We show that SSX2IP is affected in two ways which relate to the cell cycling of AML cells. In patients harbouring the t(15;17) translocation overexpression of SSX2IP is associated with an abnormal elevation in the expression of genes involved in cell cycle. Conversely in AML cells harbouring the t(8;21) translocation, the low levels of SSX2IP are associated with low levels of CDC20 protein, part of the anaphase-promoting complex which is thought to contribute to the development of aneuploidy seen in these patients
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Submitted date: January 2008
Published date: January 2008
Keywords:
AML, tumour antigens, cell cycle, chromosomal rearrangements, myeloid leukaemia antigens, tumour biology
Identifiers
Local EPrints ID: 71032
URI: http://eprints.soton.ac.uk/id/eprint/71032
ISSN: 0007-1048
PURE UUID: 0702e4b1-11b8-45c8-9cd8-32b9dc097ce4
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Date deposited: 14 Dec 2009
Last modified: 13 Mar 2024 20:17
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Contributors
Author:
Barbara-ann Guinn
Author:
Lars Bullinger
Author:
N. Shaun B. Thomas
Author:
Ken I. Mills
Author:
Jochen Greiner
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