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Design criteria for a printed tissue engineering construct: A mathematical homogenization approach

Shipley, R.J., Jones, G.W., Dyson, R.J., Sengers, B.G., Bailey, C.L., Catt, C.J., Please, C.P. and Malda, J. (2009) Design criteria for a printed tissue engineering construct: A mathematical homogenization approach Journal of Theoretical Biology, 259, (3), pp. 489-502. (doi:10.1016/j.jtbi.2009.03.037).

Record type: Article


Cartilage tissue repair procedures currently under development aim to create a construct in which patient-derived cells are seeded and expanded ex vivo before implantation back into the body. The key challenge is producing physiologically realistic constructs that mimic real tissue structure and function. One option with vast potential is to print strands of material in a 3D structure called a scaffold that imitates the real tissue structure; the strands are composed of gel seeded with cells and so provide a template for cartilaginous tissue growth. The scaffold is placed in the construct and pumped with nutrient-rich culture medium to supply nutrients to the cells and remove waste products, thus promoting tissue growth.
In this paper we use asymptotic homogenization to determine the effective flow and transport properties of such a printed scaffold system. These properties are used to predict the distribution of nutrient/waste products through the construct, and to specify design criteria for the scaffold that will optimize the growth of functional tissue

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Submitted date: 27 October 2008
Published date: 7 August 2009
Keywords: cartilage, perfusion, scaffold, construct, mathematical modelling, averaging, species transport
Organisations: Bioengineering Sciences, Mathematics


Local EPrints ID: 71596
ISSN: 0022-5193
PURE UUID: b403cf8f-a97b-4a4b-ac7f-8050094279ae
ORCID for B.G. Sengers: ORCID iD

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Date deposited: 15 Dec 2009
Last modified: 18 Jul 2017 23:59

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Author: R.J. Shipley
Author: G.W. Jones
Author: R.J. Dyson
Author: B.G. Sengers ORCID iD
Author: C.L. Bailey
Author: C.J. Catt
Author: C.P. Please
Author: J. Malda

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