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Frequent expression of HAGE in presentation chronic myeloid leukaemias

Frequent expression of HAGE in presentation chronic myeloid leukaemias
Frequent expression of HAGE in presentation chronic myeloid leukaemias
Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments.
cancer-testis antigens, myeloid leukaemia, gene expression, immunotherapy
0887-6924
2238-2242
Adams, S.P.
6faff784-92bb-4685-bffe-ca02a81dcbc2
Sahota, S.S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Mijovic, A.
440c1a29-9fda-43aa-906a-bad8bbe4c038
Czepulkowski, B.
f5acd97d-95b1-4792-9d74-7014df0e0826
Padua, R.A.
a80243f6-86ac-47eb-80aa-9eae19d53892
Mufti, G.J.
eb54cd2e-96a6-4105-88a2-5c82340947ac
Guinn, B.A.
30273eb5-489d-4f00-816e-55d73a43b7c7
Adams, S.P.
6faff784-92bb-4685-bffe-ca02a81dcbc2
Sahota, S.S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Mijovic, A.
440c1a29-9fda-43aa-906a-bad8bbe4c038
Czepulkowski, B.
f5acd97d-95b1-4792-9d74-7014df0e0826
Padua, R.A.
a80243f6-86ac-47eb-80aa-9eae19d53892
Mufti, G.J.
eb54cd2e-96a6-4105-88a2-5c82340947ac
Guinn, B.A.
30273eb5-489d-4f00-816e-55d73a43b7c7

Adams, S.P., Sahota, S.S., Mijovic, A., Czepulkowski, B., Padua, R.A., Mufti, G.J. and Guinn, B.A. (2002) Frequent expression of HAGE in presentation chronic myeloid leukaemias. Leukemia, 16, 2238-2242. (doi:10.1038/sj.leu.2402732).

Record type: Article

Abstract

Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments.

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Published date: 2002
Keywords: cancer-testis antigens, myeloid leukaemia, gene expression, immunotherapy

Identifiers

Local EPrints ID: 71598
URI: http://eprints.soton.ac.uk/id/eprint/71598
ISSN: 0887-6924
PURE UUID: 7d928a3a-653a-4a08-9777-e26fc12d2cdb

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Date deposited: 16 Dec 2009
Last modified: 19 Jul 2019 23:44

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Contributors

Author: S.P. Adams
Author: S.S. Sahota
Author: A. Mijovic
Author: B. Czepulkowski
Author: R.A. Padua
Author: G.J. Mufti
Author: B.A. Guinn

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