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Chronic surgical site infection due to suture-associated polymicrobial biofilm

Kathju, Sandeep, Nistico, Laura, Hall-Stoodley, Luanne, Post, J. Christopher, Ehrlich, Garth D. and Stoodley, Paul (2009) Chronic surgical site infection due to suture-associated polymicrobial biofilm Surgical Infections, 10, (5), pp. 457-461. (doi:10.1089/sur.2008.062).

Record type: Article


Background: surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management.
Methods: examination of explanted foreign bodies (sutures) using confocal laser scanning microscopy (CLSM) and fluorescent in situ hybridization (FISH) after surgical exploration of a chronic culture-negative SSI.
Results: confocal microscopy (CM) demonstrated bacilli and cocci attached to the surface of the explanted sutures in a mixed biofilm. Florescent in situ hybridization confirmed that Staphylococci were components of the mixed biofilm. Removal of the foreign bodies (sutures) resolved the chronic infection.
Conclusion: chronic SSI can arise from underlying bacterial biofilms, which can invest implanted foreign bodies and associated soft tissue surfaces

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Published date: November 2009
Additional Information: The National Centre for Advanced Tribology at Southampton (nCATS)


Local EPrints ID: 71638
ISSN: 1096-2964
PURE UUID: b692bc46-b59b-46b4-9acf-30117e62d3fd

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Date deposited: 18 Dec 2009
Last modified: 18 Jul 2017 23:59

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Author: Sandeep Kathju
Author: Laura Nistico
Author: Luanne Hall-Stoodley
Author: J. Christopher Post
Author: Garth D. Ehrlich
Author: Paul Stoodley

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