Evolving concepts in biofilm infections
Evolving concepts in biofilm infections
Several pathogens associated with chronic infections, including Pseudomonas aeruginosa in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in chronic otitis media, Staphylococcus aureus in chronic rhinosinusitis and enteropathogenic Escherichia coli in recurrent urinary tract infections, are linked to biofilm formation. Biofilms are usually defined as surface-associated microbial communities, surrounded by an extracellular polymeric substance (EPS) matrix. Biofilm formation has been demonstrated for numerous pathogens and is clearly an important microbial survival strategy. However, outside of dental plaques, fewer reports have investigated biofilm development in clinical samples. Typically biofilms are found in chronic diseases that resist host immune responses and antibiotic treatment and these characteristics are often cited for the ability of bacteria to persist in vivo. This review examines some recent attempts to examine the biofilm phenotype in vivo and discusses the challenges and implications for defining a biofilm phenotype
1034-1043
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
July 2009
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Abstract
Several pathogens associated with chronic infections, including Pseudomonas aeruginosa in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in chronic otitis media, Staphylococcus aureus in chronic rhinosinusitis and enteropathogenic Escherichia coli in recurrent urinary tract infections, are linked to biofilm formation. Biofilms are usually defined as surface-associated microbial communities, surrounded by an extracellular polymeric substance (EPS) matrix. Biofilm formation has been demonstrated for numerous pathogens and is clearly an important microbial survival strategy. However, outside of dental plaques, fewer reports have investigated biofilm development in clinical samples. Typically biofilms are found in chronic diseases that resist host immune responses and antibiotic treatment and these characteristics are often cited for the ability of bacteria to persist in vivo. This review examines some recent attempts to examine the biofilm phenotype in vivo and discusses the challenges and implications for defining a biofilm phenotype
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Published date: July 2009
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The National Centre for Advanced Tribology at Southampton (nCATS)
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Local EPrints ID: 71657
URI: http://eprints.soton.ac.uk/id/eprint/71657
ISSN: 1462-5814
PURE UUID: 303178bc-197b-47c9-b4cc-ccf902f5ff67
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Date deposited: 17 Dec 2009
Last modified: 14 Mar 2024 02:55
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Author:
Luanne Hall-Stoodley
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