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Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy

Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy
Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy
The pathological changes in osteoarthritis—a degenerative joint disease prevalent among older people—start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage. At present, there are no treatments to cure or attenuate the degradation of cartilage. Early detection and the ability to monitor the progression of osteoarthritis are therefore important for developing effective therapies. Here, we show that indentation-type atomic force microscopy can monitor age-related morphological and biomechanical changes in the hips of normal and osteoarthritic mice. Early damage in the cartilage of osteoarthritic patients undergoing hip or knee replacements could similarly be detected using this method. Changes due to aging and osteoarthritis are clearly depicted at the nanometre scale well before morphological changes can be observed using current diagnostic methods. Indentation-type atomic force microscopy may potentially be developed into a minimally invasive arthroscopic tool to diagnose the early onset of osteoarthritis in situ
1748-3387
186-192
Stolz, Martin
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Gottardi, Riccardo
a88c943c-3271-4488-be52-0414be425f36
Raiteri, Roberto
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Miot, Sylvie
479ff92d-38f7-495f-b6cf-fcc08b984e65
Martin, Ivan
a6c0b810-3113-43cd-aa25-243a5f05364b
Imer, Raphael
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Staufer, Urs
dbcb030b-a10a-471a-a89e-575a2410d030
Raducanu, Aurelia
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Duggelin, Marcel
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Baschong, Werner
f5bf0ecb-f5b3-438c-a799-121eea8c5149
Daniels, A.U.
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Friederich, Niklaus F.
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Aszodi, Attila
c4a26d53-fbc7-4470-b69d-cbc6131111d6
Aebi, Ueli
ea7e2491-b815-4ea3-a657-28e2e057f09f
Stolz, Martin
7bfa1d59-511d-471b-96ce-679b343b5d1d
Gottardi, Riccardo
a88c943c-3271-4488-be52-0414be425f36
Raiteri, Roberto
6242d937-2e7f-4b42-a19e-320f9b420144
Miot, Sylvie
479ff92d-38f7-495f-b6cf-fcc08b984e65
Martin, Ivan
a6c0b810-3113-43cd-aa25-243a5f05364b
Imer, Raphael
978097c3-2e6d-4ae0-a45a-b4f6a8053498
Staufer, Urs
dbcb030b-a10a-471a-a89e-575a2410d030
Raducanu, Aurelia
54a91f1e-3e45-4035-900c-d8820e28910b
Duggelin, Marcel
95460cc0-3c14-494e-b1b8-bb2844384248
Baschong, Werner
f5bf0ecb-f5b3-438c-a799-121eea8c5149
Daniels, A.U.
79d2d48d-1aa7-4584-9924-5328ca4c8650
Friederich, Niklaus F.
431eff65-1a1c-4996-a258-bbaa3b94d7f5
Aszodi, Attila
c4a26d53-fbc7-4470-b69d-cbc6131111d6
Aebi, Ueli
ea7e2491-b815-4ea3-a657-28e2e057f09f

Stolz, Martin, Gottardi, Riccardo, Raiteri, Roberto, Miot, Sylvie, Martin, Ivan, Imer, Raphael, Staufer, Urs, Raducanu, Aurelia, Duggelin, Marcel, Baschong, Werner, Daniels, A.U., Friederich, Niklaus F., Aszodi, Attila and Aebi, Ueli (2009) Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy. Nature Nanotechnology, 4, 186-192. (doi:10.1038/nnano.2008.410).

Record type: Article

Abstract

The pathological changes in osteoarthritis—a degenerative joint disease prevalent among older people—start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage. At present, there are no treatments to cure or attenuate the degradation of cartilage. Early detection and the ability to monitor the progression of osteoarthritis are therefore important for developing effective therapies. Here, we show that indentation-type atomic force microscopy can monitor age-related morphological and biomechanical changes in the hips of normal and osteoarthritic mice. Early damage in the cartilage of osteoarthritic patients undergoing hip or knee replacements could similarly be detected using this method. Changes due to aging and osteoarthritis are clearly depicted at the nanometre scale well before morphological changes can be observed using current diagnostic methods. Indentation-type atomic force microscopy may potentially be developed into a minimally invasive arthroscopic tool to diagnose the early onset of osteoarthritis in situ

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More information

Published date: March 2009
Additional Information: The National Centre for Advanced Tribology at Southampton (nCATS)
Organisations: Engineering Sciences

Identifiers

Local EPrints ID: 71689
URI: http://eprints.soton.ac.uk/id/eprint/71689
ISSN: 1748-3387
PURE UUID: 2f3b8203-0c2f-4317-8e02-ec5585a99120
ORCID for Martin Stolz: ORCID iD orcid.org/0000-0002-0732-0811

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Date deposited: 23 Dec 2009
Last modified: 14 Mar 2024 02:55

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Contributors

Author: Martin Stolz ORCID iD
Author: Riccardo Gottardi
Author: Roberto Raiteri
Author: Sylvie Miot
Author: Ivan Martin
Author: Raphael Imer
Author: Urs Staufer
Author: Aurelia Raducanu
Author: Marcel Duggelin
Author: Werner Baschong
Author: A.U. Daniels
Author: Niklaus F. Friederich
Author: Attila Aszodi
Author: Ueli Aebi

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