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Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy

Stolz, Martin, Gottardi, Riccardo, Raiteri, Roberto, Miot, Sylvie, Martin, Ivan, Imer, Raphael, Staufer, Urs, Raducanu, Aurelia, Duggelin, Marcel, Baschong, Werner, Daniels, A.U., Friederich, Niklaus F., Aszodi, Attila and Aebi, Ueli (2009) Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy Nature Nanotechnology, 4, pp. 186-192. (doi:10.1038/nnano.2008.410).

Record type: Article


The pathological changes in osteoarthritis—a degenerative joint disease prevalent among older people—start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage. At present, there are no treatments to cure or attenuate the degradation of cartilage. Early detection and the ability to monitor the progression of osteoarthritis are therefore important for developing effective therapies. Here, we show that indentation-type atomic force microscopy can monitor age-related morphological and biomechanical changes in the hips of normal and osteoarthritic mice. Early damage in the cartilage of osteoarthritic patients undergoing hip or knee replacements could similarly be detected using this method. Changes due to aging and osteoarthritis are clearly depicted at the nanometre scale well before morphological changes can be observed using current diagnostic methods. Indentation-type atomic force microscopy may potentially be developed into a minimally invasive arthroscopic tool to diagnose the early onset of osteoarthritis in situ

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Published date: March 2009
Additional Information: The National Centre for Advanced Tribology at Southampton (nCATS)
Organisations: Engineering Sciences


Local EPrints ID: 71689
ISSN: 1748-3387
PURE UUID: 2f3b8203-0c2f-4317-8e02-ec5585a99120

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Date deposited: 23 Dec 2009
Last modified: 18 Jul 2017 23:59

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Author: Martin Stolz
Author: Riccardo Gottardi
Author: Roberto Raiteri
Author: Sylvie Miot
Author: Ivan Martin
Author: Raphael Imer
Author: Urs Staufer
Author: Aurelia Raducanu
Author: Marcel Duggelin
Author: Werner Baschong
Author: A.U. Daniels
Author: Niklaus F. Friederich
Author: Attila Aszodi
Author: Ueli Aebi

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