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Evaluation of a new high power, wide separation laser Doppler probe: potential measurement of deeper tissue blood flow

Clough, Geraldine F., Chipperfield, Andrew, Byrne, Christopher, de Mul, Frits and Gush, Rodney (2009) Evaluation of a new high power, wide separation laser Doppler probe: potential measurement of deeper tissue blood flow Microvascular Research, 78, (2), pp. 155-161. (doi:10.1016/j.mvr.2009.05.003).

Record type: Article


Objective: to compare the output from a novel high power, wide separation laser Doppler flow probe (DP1-V2-HP, 4mm with IRLD20) with that of a standard flow probe (DP1-V2, 0.5mm, with DRT4) (Moor UK) and to explore its potential for use in the nonivasive measurement of blood flow in deeper tissues in humans.

Methods: Monte Carlo modeling was used to predict depths of light scattering in skin with each probe, geometry. Experimentally, forearm blood flow was measured at rest and during local warming of the skin surface and post occlusion reactive hyperaemia (PORH). Laser Doppler blood flus (LDF) and the power spectral density of its component frequency intervals were compared.

Results: Monte Carlo modeling indicated that while the majority of wide probe LD signal derives from deeper tissue, a significant portion is from superficial (dermal) tissue (and vice versa for standard probe). Perturbation of local blood flow differentially increased LDF and spectral power as measured by the two probes, with the standard skin probe showing a significantly greater response to local skin warming.

Conclusions: these differences support our hypothesis that the wide probe is recording predominantly blood flux within the vasculature of sub-dermal tissue. This is in agreement with Monte Carlo simulation.

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Submitted date: 23 April 2009
Published date: 19 September 2009
Keywords: laser doppler blood flow, skin, sub-dermal tissue, skin warming, monte carlo modeling
Organisations: Computational Engineering and Design, Medicine


Local EPrints ID: 71745
ISSN: 0026-2862
PURE UUID: 0c1d5b38-6bcf-44dc-997f-0f7e57720ae0
ORCID for Geraldine F. Clough: ORCID iD
ORCID for Andrew Chipperfield: ORCID iD

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Date deposited: 04 Jan 2010
Last modified: 18 Jul 2017 23:58

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