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Skeletal muscle microvascular exchange capacity is associated with hyperglycaemia in subjects with central obesity

Record type: Article

Aims: poor glycaemic control is associated with increased risk of microvascular disease in various organs including the eye and kidney, but the relationship between glycated haemoglobin (HbA1c) and microvascular function in skeletal muscle has not been described. We tested the association between HbA1c and a measure of microvascular exchange capacity (Kf) in skeletal muscle in people with central obesity at risk of developing Type 2 diabetes.
Methods: microvascular function was measured in 28 women and 19 men [mean (± sd) age 51 ± 9 years] with central obesity who did not have diabetes. We estimated insulin sensitivity by hyperinsulinaemic–euglycaemic clamp, visceral and total fatness by magnetic resonance imaging, fitness (VO2 max by treadmill testing), physical activity energy expenditure [metabolic equivalents of tasks (METS) by use of the SenseWear Pro armband] and skeletal muscle microvascular exchange capacity (Kf) by venous occlusion plethysmography.
Results: in regression modelling, age, sex and fasting plasma glucose accounted for 30.5% of the variance in HbA1c (r2 = 0.31, P = 0.001). Adding Kf to this model explained an additional 26.5% of the variance in HbA1c (r2 = 0.57, P = 0.0001 and Kf was strongly and independently associated with HbA1c (standardized B coefficient ?0.45 (95% confidence interval ?0.19, ?0.06), P = 0.001).
Conclusions: we found a strong negative independent association between a measure of skeletal muscle microvascular exchange capacity (Kf) and HbA1c. Kf was associated with almost as much of the variance in HbA1c as fasting plasma glucose

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Citation

Turzyniecka, M., Wild, S.H., Krentz, A.J., Chipperfield, A.J., Gamble, J., Clough, G.F. and Byrne, C.D. (2009) Skeletal muscle microvascular exchange capacity is associated with hyperglycaemia in subjects with central obesity Diabetic Medicine, 26, (11), pp. 1112-1119. (doi:10.1111/j.1464-5491.2009.02822.x).

More information

Published date: November 2009
Keywords: glycated haemoglobin, insulin sensitivity, microcirculation, obesity
Organisations: Computational Engineering and Design, Medicine

Identifiers

Local EPrints ID: 71747
URI: http://eprints.soton.ac.uk/id/eprint/71747
ISSN: 0742-3071
PURE UUID: aeca3c51-1ab8-4963-9e41-832b9e0d1a77
ORCID for A.J. Chipperfield: ORCID iD orcid.org/0000-0002-3026-9890
ORCID for G.F. Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 04 Jan 2010
Last modified: 18 Jul 2017 23:59

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