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Mode-switching: a new technique for electronically varying the agglomeration position in an acoustic particle manipulator

Mode-switching: a new technique for electronically varying the agglomeration position in an acoustic particle manipulator
Mode-switching: a new technique for electronically varying the agglomeration position in an acoustic particle manipulator
Acoustic radiation forces offer a means of manipulating particles within a fluid. Much interest in recent years has focussed on the use of radiation forces in microfluidic (or “lab on a chip”) devices. Such devices are well matched to the use of ultrasonic standing waves in which the resonant dimensions of the chamber are smaller than the ultrasonic wavelength in use. However, such devices have typically been limited to moving particles to one or two predetermined planes, whose positions are determined by acoustic pressure nodes/anti-nodes set up in the ultrasonic standing wave. In most cases devices have been designed to move particles to either the centre or (more recently) the side of a flow channel using ultrasonic frequencies that produce a half or quarter wavelength over the channel, respectively.
It is demonstrated here that by rapidly switching back and forth between half and quarter wavelength frequencies – mode-switching – a new agglomeration position is established that permits beads to be brought to any arbitrary point between the half and quarter-wave nodes. This new agglomeration position is effectively a position of stable equilibrium. This has many potential applications, particularly in cell sorting and manipulation. It should also enable precise control of agglomeration position to be maintained regardless of manufacturing tolerances, temperature variations, fluid medium characteristics and particle concentration
ultrasonic particle manipulation, acoustic radiation force, layered resonators, microfluidics, mode-switching
0041-624X
68-75
Glynne-Jones, Peter
6ca3fcbc-14db-4af9-83e2-cf7c8b91ef0d
Boltryk, Rosemary J.
0452b21c-a758-4d4a-925b-1511d9296d62
Harris, Nicholas R.
237cfdbd-86e4-4025-869c-c85136f14dfd
Cranny, Andy W.J.
2ebc2ccb-7d3e-4a6a-91ac-9f089741939e
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Glynne-Jones, Peter
6ca3fcbc-14db-4af9-83e2-cf7c8b91ef0d
Boltryk, Rosemary J.
0452b21c-a758-4d4a-925b-1511d9296d62
Harris, Nicholas R.
237cfdbd-86e4-4025-869c-c85136f14dfd
Cranny, Andy W.J.
2ebc2ccb-7d3e-4a6a-91ac-9f089741939e
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e

Glynne-Jones, Peter, Boltryk, Rosemary J., Harris, Nicholas R., Cranny, Andy W.J. and Hill, Martyn (2010) Mode-switching: a new technique for electronically varying the agglomeration position in an acoustic particle manipulator Ultrasonics, 50, (1), pp. 68-75.

Record type: Article

Abstract

Acoustic radiation forces offer a means of manipulating particles within a fluid. Much interest in recent years has focussed on the use of radiation forces in microfluidic (or “lab on a chip”) devices. Such devices are well matched to the use of ultrasonic standing waves in which the resonant dimensions of the chamber are smaller than the ultrasonic wavelength in use. However, such devices have typically been limited to moving particles to one or two predetermined planes, whose positions are determined by acoustic pressure nodes/anti-nodes set up in the ultrasonic standing wave. In most cases devices have been designed to move particles to either the centre or (more recently) the side of a flow channel using ultrasonic frequencies that produce a half or quarter wavelength over the channel, respectively.
It is demonstrated here that by rapidly switching back and forth between half and quarter wavelength frequencies – mode-switching – a new agglomeration position is established that permits beads to be brought to any arbitrary point between the half and quarter-wave nodes. This new agglomeration position is effectively a position of stable equilibrium. This has many potential applications, particularly in cell sorting and manipulation. It should also enable precise control of agglomeration position to be maintained regardless of manufacturing tolerances, temperature variations, fluid medium characteristics and particle concentration

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More information

Submitted date: January 2008
Published date: January 2010
Keywords: ultrasonic particle manipulation, acoustic radiation force, layered resonators, microfluidics, mode-switching

Identifiers

Local EPrints ID: 71767
URI: http://eprints.soton.ac.uk/id/eprint/71767
ISSN: 0041-624X
PURE UUID: 4b93f431-bfa8-48ab-8e1c-65326d7d87ab
ORCID for Peter Glynne-Jones: ORCID iD orcid.org/0000-0001-5684-3953
ORCID for Nicholas R. Harris: ORCID iD orcid.org/0000-0003-4122-2219
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

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Date deposited: 04 Jan 2010
Last modified: 10 Nov 2017 09:52

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