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Design, simulation and characterisation of integrated optics for a microfabricated flow cytometer

Barat, David, Benazzi, Guiseppe, Mowlem, Matthew Charles, Ruano, Jesus Miguel and Morgan, Hywel (2010) Design, simulation and characterisation of integrated optics for a microfabricated flow cytometer Optics Communications, 283, (9), pp. 1987-1992. (doi:10.1016/j.optcom.2009.12.046).

Record type: Article

Abstract

Flow cytometry is widely used for analyzing micro-particles such as cells and bacteria. Microfabricated flow cytometers promise reduced instrument size and cost with increased robustness and have application in medicine, life sciences and environmental metrology. Further miniaturisation and robustness can be achieved if integrated optics are used instead of traditional free space optics. We present designs simulation and experimental characterisation of integrated optics for a microfabricated cytometer made from SU-8 resin on a glass substrate. The optics constructed from combinations of optical fibres (positioned with microgrooves), waveguides, and microlenses enable analysis of scattered light and fluorescence from particles positioned near the centre of a microchannel using one dimensional sheath flow. Four different methods for directing the incident light onto the particles are examined and the optimum design discussed.

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More information

Published date: 1 May 2010
Organisations: Ocean Technology and Engineering

Identifiers

Local EPrints ID: 72160
URI: http://eprints.soton.ac.uk/id/eprint/72160
ISSN: 0030-4018
PURE UUID: ec6d718a-b93a-4c9b-8c3f-7b1c181131f2
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 26 Jan 2010
Last modified: 18 Jul 2017 23:55

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