Design, simulation and characterisation of integrated optics for a microfabricated flow cytometer


Barat, David, Benazzi, Guiseppe, Mowlem, Matthew Charles, Ruano, Jesus Miguel and Morgan, Hywel (2010) Design, simulation and characterisation of integrated optics for a microfabricated flow cytometer Optics Communications, 283, (9), pp. 1987-1992. (doi:10.1016/j.optcom.2009.12.046).

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Description/Abstract

Flow cytometry is widely used for analyzing micro-particles such as cells and bacteria. Microfabricated flow cytometers promise reduced instrument size and cost with increased robustness and have application in medicine, life sciences and environmental metrology. Further miniaturisation and robustness can be achieved if integrated optics are used instead of traditional free space optics. We present designs simulation and experimental characterisation of integrated optics for a microfabricated cytometer made from SU-8 resin on a glass substrate. The optics constructed from combinations of optical fibres (positioned with microgrooves), waveguides, and microlenses enable analysis of scattered light and fluorescence from particles positioned near the centre of a microchannel using one dimensional sheath flow. Four different methods for directing the incident light onto the particles are examined and the optimum design discussed.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.optcom.2009.12.046
ISSNs: 0030-4018 (print)
Subjects:
Organisations: Ocean Technology and Engineering
ePrint ID: 72160
Date :
Date Event
1 May 2010Published
Date Deposited: 26 Jan 2010
Last Modified: 18 Apr 2017 20:57
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/72160

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