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Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

Coppola, Eva, Rallu, Murielle, Richard, Juliette, Dufour, Sylvie, Riethmacher, Dieter, Guillemot, François, Goridis, Christo and Brunet, Jean-François (2010) Epibranchial ganglia orchestrate the development of the cranial neurogenic crest Proceedings of the National Academy of Sciences, 107, (5), pp. 2066-2071. (doi:10.1073/pnas.0910213107).

Record type: Article

Abstract

The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat of biological engineering appears to rely on sequences of pathfinding decisions upon local cues, each with little relationship to the anatomical and physiological outcome. Here, we uncover a straightforward cellular mechanism for circuit building whereby a neuronal type directs the development of its future partners. We show that visceral afferents of the head (that innervate taste buds) provide a scaffold for the establishment of visceral efferents (that innervate salivatory glands and blood vessels). In embryological terms, sensory neurons derived from an epibranchial placode—that we show to develop largely independently from the neural crest—guide the directional outgrowth of hindbrain visceral motoneurons and control the formation of neural crest–derived parasympathetic ganglia.

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More information

Submitted date: 10 September 2009
Published date: 2 February 2010
Keywords: autonomic nervous system, epibranchial placode, neural circuit, Phox2b, neural crest
Organisations: Human Genetics

Identifiers

Local EPrints ID: 72253
URI: http://eprints.soton.ac.uk/id/eprint/72253
ISSN: 0027-8424
PURE UUID: 0cd8199e-7831-4ac0-995d-2c6a6adefa1c

Catalogue record

Date deposited: 03 Feb 2010
Last modified: 18 Jul 2017 23:55

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Contributors

Author: Eva Coppola
Author: Murielle Rallu
Author: Juliette Richard
Author: Sylvie Dufour
Author: François Guillemot
Author: Christo Goridis
Author: Jean-François Brunet

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