Proteomics in prostate cancer biomarker discovery
Proteomics in prostate cancer biomarker discovery
Despite advances in molecular medicine, genomics, proteomics and translational research, prostate cancer remains the second most common cause of cancer-related mortality for men in the Western world. Clearly, early detection, targeted treatment and post-treatment monitoring are vital tools to combat this disease. Tumor markers can be useful for diagnosis and early detection of cancer, assessment of prognosis, prediction of therapeutic effect and treatment monitoring. Such tumor markers include prostate-specific antigen (prostate), cancer antigen (CA)15.3 (breast), CA125 (ovarian), CA19.9 (gastrointestinal) and serum ?-fetoprotein (testicular cancer). However, all of these biomarkers lack sensitivity and specificity and, therefore, there is a large drive towards proteomic biomarker discovery. Current research efforts are directed towards discovering biosignatures from biological samples using novel proteomic technologies that provide high-throughput, in-depth analysis and quantification of the proteome. Several of these studies have revealed promising biomarkers for use in diagnosis, assessment of prognosis, and targeting treatment of prostate cancer. This review focuses on prostate cancer proteomic biomarker discovery and its future potential.
93-102
Larkin, Samantha E.T.
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Zeidan, Bashar
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Taylor, Matthew G.
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Bickers, Bridget
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Al-Ruwaili, Jamal
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Aukim-Hastie, Claire
694982c6-0b76-4d0e-948c-eef554e9aa88
Townsend, Paul A.
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February 2010
Larkin, Samantha E.T.
73ffb031-2115-47e3-a62f-907d687d108f
Zeidan, Bashar
5c2d2181-6914-419b-a213-b54d293c88a2
Taylor, Matthew G.
1978fa0d-36ff-41e4-929f-d21eba8c1bf4
Bickers, Bridget
a80bafdc-a05e-432d-ac1b-80ab75bc26c5
Al-Ruwaili, Jamal
ca7b24c2-e847-4010-bb1f-bcbe321e10a5
Aukim-Hastie, Claire
694982c6-0b76-4d0e-948c-eef554e9aa88
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Larkin, Samantha E.T., Zeidan, Bashar, Taylor, Matthew G., Bickers, Bridget, Al-Ruwaili, Jamal, Aukim-Hastie, Claire and Townsend, Paul A.
(2010)
Proteomics in prostate cancer biomarker discovery.
Expert Review of Proteomics, 7 (1), .
(doi:10.1586/EPR.09.89).
Abstract
Despite advances in molecular medicine, genomics, proteomics and translational research, prostate cancer remains the second most common cause of cancer-related mortality for men in the Western world. Clearly, early detection, targeted treatment and post-treatment monitoring are vital tools to combat this disease. Tumor markers can be useful for diagnosis and early detection of cancer, assessment of prognosis, prediction of therapeutic effect and treatment monitoring. Such tumor markers include prostate-specific antigen (prostate), cancer antigen (CA)15.3 (breast), CA125 (ovarian), CA19.9 (gastrointestinal) and serum ?-fetoprotein (testicular cancer). However, all of these biomarkers lack sensitivity and specificity and, therefore, there is a large drive towards proteomic biomarker discovery. Current research efforts are directed towards discovering biosignatures from biological samples using novel proteomic technologies that provide high-throughput, in-depth analysis and quantification of the proteome. Several of these studies have revealed promising biomarkers for use in diagnosis, assessment of prognosis, and targeting treatment of prostate cancer. This review focuses on prostate cancer proteomic biomarker discovery and its future potential.
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Published date: February 2010
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Local EPrints ID: 72270
URI: http://eprints.soton.ac.uk/id/eprint/72270
PURE UUID: 38254f70-244e-4716-95c4-74fb1050569f
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Date deposited: 12 Feb 2010
Last modified: 13 Mar 2024 21:22
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Contributors
Author:
Samantha E.T. Larkin
Author:
Bashar Zeidan
Author:
Matthew G. Taylor
Author:
Bridget Bickers
Author:
Jamal Al-Ruwaili
Author:
Claire Aukim-Hastie
Author:
Paul A. Townsend
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