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Regulating the genome surveillance system: miRNAs and the p53 super family

Regulating the genome surveillance system: miRNAs and the p53 super family
Regulating the genome surveillance system: miRNAs and the p53 super family
The p53 gene super family consists of three members; TP53, TP63 and TP73, encoding proteins p53, p63 and p73. Whilst p63 appears to have an essential role in embryonic development with a less clear role in carcinogenesis, irregularities in p53 and p73 signalling are implicated in tumour formation. As such, p53 is a tumour suppressor which is mutated in over 50% cancers and p73 was recently formally classified as a tumour suppressor based on data showing p73 deficient mice generate spontaneous tumours similar to those observed in p53 null mice. Dysregulation of both p53 and p73 has been correlated with cancer progression in many cell types and although mutation of these genes is often observed, some form of p53/p73 deregulation likely occurs in all tumour cells. The discovery that complementary micro RNAs (miRNAs) are able to target both of these genes provides a potential new means of perturbing p53/p73 signalling networks in cancer cells. Here we summarise the current literature regarding the involvement of miRNAs in the modulation of p53 family proteins and cancer development and detail the use of in silico methods to reveal key miRNA targets
p73, miRNA, p53, leukaemia, lymphoma
1360-8185
541-552
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db

Bailey, Sarah G., Sanchez-Elsner, Tilman, Stephanou, Anastasis, Cragg, Mark S. and Townsend, Paul A. (2010) Regulating the genome surveillance system: miRNAs and the p53 super family. Apoptosis, 15 (5), 541-552. (doi:10.1007/s10495-010-0456-1).

Record type: Article

Abstract

The p53 gene super family consists of three members; TP53, TP63 and TP73, encoding proteins p53, p63 and p73. Whilst p63 appears to have an essential role in embryonic development with a less clear role in carcinogenesis, irregularities in p53 and p73 signalling are implicated in tumour formation. As such, p53 is a tumour suppressor which is mutated in over 50% cancers and p73 was recently formally classified as a tumour suppressor based on data showing p73 deficient mice generate spontaneous tumours similar to those observed in p53 null mice. Dysregulation of both p53 and p73 has been correlated with cancer progression in many cell types and although mutation of these genes is often observed, some form of p53/p73 deregulation likely occurs in all tumour cells. The discovery that complementary micro RNAs (miRNAs) are able to target both of these genes provides a potential new means of perturbing p53/p73 signalling networks in cancer cells. Here we summarise the current literature regarding the involvement of miRNAs in the modulation of p53 family proteins and cancer development and detail the use of in silico methods to reveal key miRNA targets

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More information

Published date: May 2010
Keywords: p73, miRNA, p53, leukaemia, lymphoma
Organisations: Human Genetics, Cancer Sciences, Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 72419
URI: https://eprints.soton.ac.uk/id/eprint/72419
ISSN: 1360-8185
PURE UUID: 09d41578-2c56-4911-a2b4-72e5fda4064e
ORCID for Mark S. Cragg: ORCID iD orcid.org/0000-0003-2077-089X

Catalogue record

Date deposited: 12 Feb 2010
Last modified: 06 Jun 2018 12:58

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