Minireview: transgenerational inheritance of the stress response: a new frontier in stress research
Minireview: transgenerational inheritance of the stress response: a new frontier in stress research
It is well established in animal models that the prenatal environment can have a major impact on stress axis function throughout life. These changes can predispose to various metabolic, cardiovascular, and neurobiological pathophysiologies. Emerging evidence indicates that the same programming effects occur in humans. It is now becoming clear that the pathophysiological effects are not confined to the first-generation offspring and that there is transgenerational memory of fetal experience that can extend across multiple generations. The complex mechanisms by which transgenerational transmission of stress responsiveness occur are rapidly becoming a focus of investigation. Understanding these fundamental biological processes will allow for development of intervention strategies that prevent or reverse adverse programming of the stress response.
7-13
Matthews, Stephen G.
c014a3e1-757b-4727-b228-4554200e32f6
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
January 2010
Matthews, Stephen G.
c014a3e1-757b-4727-b228-4554200e32f6
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Matthews, Stephen G. and Phillips, David I.W.
(2010)
Minireview: transgenerational inheritance of the stress response: a new frontier in stress research.
Endocrinology, 151 (1), .
(doi:10.1210/en.2009-0916).
Abstract
It is well established in animal models that the prenatal environment can have a major impact on stress axis function throughout life. These changes can predispose to various metabolic, cardiovascular, and neurobiological pathophysiologies. Emerging evidence indicates that the same programming effects occur in humans. It is now becoming clear that the pathophysiological effects are not confined to the first-generation offspring and that there is transgenerational memory of fetal experience that can extend across multiple generations. The complex mechanisms by which transgenerational transmission of stress responsiveness occur are rapidly becoming a focus of investigation. Understanding these fundamental biological processes will allow for development of intervention strategies that prevent or reverse adverse programming of the stress response.
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Published date: January 2010
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Local EPrints ID: 72476
URI: http://eprints.soton.ac.uk/id/eprint/72476
ISSN: 0013-7227
PURE UUID: 1d186028-72a0-4f89-a3d8-77cce14c0edc
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Date deposited: 16 Feb 2010
Last modified: 13 Mar 2024 21:31
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Author:
Stephen G. Matthews
Author:
David I.W. Phillips
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