Developmental origins of metabolic disease: life course and intergenerational perspectives
Developmental origins of metabolic disease: life course and intergenerational perspectives
Recent evidence demonstrates important maternal effects on an offspring's risk of developing metabolic disease. These effects extend across the full range of maternal environments and partly involve epigenetic mechanisms. The maternal effects can be explained in evolutionary terms, and there is some evidence for their transmission into succeeding generations. Unbalanced maternal diet or body composition, ranging from poor to rich environments, adversely influences the offspring's response to later challenges such as an obesogenic diet or physical inactivity, increasing the risk of disease. Adopting a life course approach that takes into account intergenerational effects has important implications for prevention of non-communicable diseases, particularly in populations undergoing rapid economic transition
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Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
2010
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Godfrey, Keith M., Gluckman, Peter D. and Hanson, Mark A.
(2010)
Developmental origins of metabolic disease: life course and intergenerational perspectives.
Trends in Endocrinology & Metabolism, .
(doi:10.1016/j.tem.2009.12.008).
Abstract
Recent evidence demonstrates important maternal effects on an offspring's risk of developing metabolic disease. These effects extend across the full range of maternal environments and partly involve epigenetic mechanisms. The maternal effects can be explained in evolutionary terms, and there is some evidence for their transmission into succeeding generations. Unbalanced maternal diet or body composition, ranging from poor to rich environments, adversely influences the offspring's response to later challenges such as an obesogenic diet or physical inactivity, increasing the risk of disease. Adopting a life course approach that takes into account intergenerational effects has important implications for prevention of non-communicable diseases, particularly in populations undergoing rapid economic transition
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Published date: 2010
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Local EPrints ID: 72525
URI: http://eprints.soton.ac.uk/id/eprint/72525
ISSN: 1043-2760
PURE UUID: a91e96f6-ab86-4b51-bb11-974639b6e20d
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Date deposited: 17 Feb 2010
Last modified: 14 Mar 2024 02:44
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Author:
Peter D. Gluckman
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