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Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire

Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire
Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire
Purpose: to investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.
Methods: a placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.
Results: OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.
Conclusion: regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME
otitis media, glue ear, quality of life, health state preference value, utility mapping, cross-walking
0962-9343
65-80
Dakin, Helen
a6453d0b-beb9-4da9-9c36-ee14e8373c0e
Petrou, Stavros
5ee930f5-99db-4fb8-b401-95584cff0e20
Haggard, Mark
51c26644-d6f9-4da3-951a-0e5c842644d6
Benge, Sarah
f35eb6c2-f335-40a9-baf8-19636fc29c3c
Williamson, Ian
12381296-edbf-4ac5-969b-dcb559c22f27
Dakin, Helen
a6453d0b-beb9-4da9-9c36-ee14e8373c0e
Petrou, Stavros
5ee930f5-99db-4fb8-b401-95584cff0e20
Haggard, Mark
51c26644-d6f9-4da3-951a-0e5c842644d6
Benge, Sarah
f35eb6c2-f335-40a9-baf8-19636fc29c3c
Williamson, Ian
12381296-edbf-4ac5-969b-dcb559c22f27

Dakin, Helen, Petrou, Stavros, Haggard, Mark, Benge, Sarah and Williamson, Ian (2010) Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire. Quality of Life Research, 19 (1), 65-80. (doi:10.1007/s11136-009-9558-z).

Record type: Article

Abstract

Purpose: to investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.
Methods: a placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.
Results: OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.
Conclusion: regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME

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More information

Published date: February 2010
Keywords: otitis media, glue ear, quality of life, health state preference value, utility mapping, cross-walking

Identifiers

Local EPrints ID: 72540
URI: http://eprints.soton.ac.uk/id/eprint/72540
ISSN: 0962-9343
PURE UUID: 40356563-835c-4aaa-9ebe-3fbe0ac7db79

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Date deposited: 17 Feb 2010
Last modified: 09 Jan 2022 05:50

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Contributors

Author: Helen Dakin
Author: Stavros Petrou
Author: Mark Haggard
Author: Sarah Benge
Author: Ian Williamson

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