Investigation of the natural history of forefoot bursitis detected by musculoskeletal ultrasound and predictors of its change after one year
Investigation of the natural history of forefoot bursitis detected by musculoskeletal ultrasound and predictors of its change after one year
Background: inflamed bursae (bursitis) within the forefoot are highly prevalent in
rheumatoid arthritis (RA), under diagnosed and impact heavily on patients’ pain,
mobility and quality of life. In order to optimise the management of these patients it
is essential to describe the natural history and progression of these structures over
time. The objectives were to investigate whether forefoot bursitis changes over a
one year period and if it does change to explore what predicts that change.
Methods: a cohort study design was used in which a sample of RA patients
(N¼120 from an original baseline of N¼149) who had already been assessed at
baseline were reassessed one year following their initial visit. A Diasus ultrasound
system was used to image the forefeet of all participants to determine the presence
and total occurrences of plantar forefoot bursitis. Foot pain was determined by
both subscales of the Leeds Foot Impact Scale (LFIS), impairment/footwear
(LFISIF) and activity participation limitation (LFISAP).
Results: 120 patients (98 female and 22 male) with RA (24 seronegative and
93 seropositive, 3 data missing) completed the study: mean age 60.7 (SD12.1)
years, weight 72.6 (15.3) Kg, disease duration 12.99 (10.4) years. 78 (65%) were
taking methotrexate and 55 (45.7%) anti-TNF therapy. Baseline and one year
follow up data for clinical variables are shown in Table 1.
On examination of person specific data when grouped according to occurrences
of MSUS bursitis (group1: 0–2; group2: 3–6; group3: 7–11) 31 participants had an
increase, 28 decrease and 61 had the same number of MSUS bursitis after one
year. There was a significant positive correlation between the changes in MSUS
bursitis with changes in both LFISIF (PCC¼0.216, p¼0.018) and LFISAP
(PCC¼0.193, p¼0.036) and a significant negative correlation with changes in
duration of RA (PCC¼0.269, p¼0.003).
Conclusions: the study findings imply that bursitis in the forefeet does change
over time and remains as an important factor related to RA patients’ foot pain and
disability with increases in bursitis in the forefeet being related to increases in foot
pain and disability. Furthermore bursitis in the forefeet of RA patients with longer
disease duration decreased after one year whilst those with early disease tended to
have more variance in the changes of bursitis. This suggests that regular foot
imaging assessments particularly for RA patients with early disease would be
beneficial.
Disclosures: the authors have declared no conflicts of interest
336-[i132]
Bowen, Catherine J.
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Culliford, David
622ea942-55a2-4673-970b-24c09cfa37b8
Dewbury, Keith
8190bf19-f678-4167-bece-d0a514d084e3
Sampson, Madeleine
e689ac99-ce4d-48d4-af7a-2a19cacb9d09
Burridge, Jane H.
0110e9ea-0884-4982-a003-cb6307f38f64
Edwards, Christopher J.
dcb27fec-75ea-4575-a844-3588bcf14106
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f
April 2009
Bowen, Catherine J.
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Culliford, David
622ea942-55a2-4673-970b-24c09cfa37b8
Dewbury, Keith
8190bf19-f678-4167-bece-d0a514d084e3
Sampson, Madeleine
e689ac99-ce4d-48d4-af7a-2a19cacb9d09
Burridge, Jane H.
0110e9ea-0884-4982-a003-cb6307f38f64
Edwards, Christopher J.
dcb27fec-75ea-4575-a844-3588bcf14106
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f
Bowen, Catherine J., Culliford, David, Dewbury, Keith, Sampson, Madeleine, Burridge, Jane H., Edwards, Christopher J. and Arden, Nigel K.
(2009)
Investigation of the natural history of forefoot bursitis detected by musculoskeletal ultrasound and predictors of its change after one year.
Rheumatology, 48 (Supplement 1), .
Abstract
Background: inflamed bursae (bursitis) within the forefoot are highly prevalent in
rheumatoid arthritis (RA), under diagnosed and impact heavily on patients’ pain,
mobility and quality of life. In order to optimise the management of these patients it
is essential to describe the natural history and progression of these structures over
time. The objectives were to investigate whether forefoot bursitis changes over a
one year period and if it does change to explore what predicts that change.
Methods: a cohort study design was used in which a sample of RA patients
(N¼120 from an original baseline of N¼149) who had already been assessed at
baseline were reassessed one year following their initial visit. A Diasus ultrasound
system was used to image the forefeet of all participants to determine the presence
and total occurrences of plantar forefoot bursitis. Foot pain was determined by
both subscales of the Leeds Foot Impact Scale (LFIS), impairment/footwear
(LFISIF) and activity participation limitation (LFISAP).
Results: 120 patients (98 female and 22 male) with RA (24 seronegative and
93 seropositive, 3 data missing) completed the study: mean age 60.7 (SD12.1)
years, weight 72.6 (15.3) Kg, disease duration 12.99 (10.4) years. 78 (65%) were
taking methotrexate and 55 (45.7%) anti-TNF therapy. Baseline and one year
follow up data for clinical variables are shown in Table 1.
On examination of person specific data when grouped according to occurrences
of MSUS bursitis (group1: 0–2; group2: 3–6; group3: 7–11) 31 participants had an
increase, 28 decrease and 61 had the same number of MSUS bursitis after one
year. There was a significant positive correlation between the changes in MSUS
bursitis with changes in both LFISIF (PCC¼0.216, p¼0.018) and LFISAP
(PCC¼0.193, p¼0.036) and a significant negative correlation with changes in
duration of RA (PCC¼0.269, p¼0.003).
Conclusions: the study findings imply that bursitis in the forefeet does change
over time and remains as an important factor related to RA patients’ foot pain and
disability with increases in bursitis in the forefeet being related to increases in foot
pain and disability. Furthermore bursitis in the forefeet of RA patients with longer
disease duration decreased after one year whilst those with early disease tended to
have more variance in the changes of bursitis. This suggests that regular foot
imaging assessments particularly for RA patients with early disease would be
beneficial.
Disclosures: the authors have declared no conflicts of interest
This record has no associated files available for download.
More information
Published date: April 2009
Additional Information:
Proceedings of Rheumatology '09, Glasgow, UK, 28 Apr-01 May 2009
Organisations:
Medicine, Health Sciences
Identifiers
Local EPrints ID: 72582
URI: http://eprints.soton.ac.uk/id/eprint/72582
ISSN: 1462-0324
PURE UUID: 3299e225-0929-40f1-931c-7c83d1b933b2
Catalogue record
Date deposited: 19 Feb 2010
Last modified: 14 Mar 2024 02:46
Export record
Contributors
Author:
David Culliford
Author:
Keith Dewbury
Author:
Madeleine Sampson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics