Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
In rodents, adverse prenatal nutrition, such as a maternal diet rich in fat during pregnancy, enhances susceptibility of the offspring to hypertension, type 2 diabetes and other features of the human metabolic syndrome in adulthood. However, previous experimental studies were confined to short-term modifications of the maternal diet during pregnancy and/or lactation periods, a situation uncommon in humans. Moreover in humans, the offspring may also consume a high-fat diet, which may take them beyond the range to which their development has adapted them to respond healthily. We examined in C57 mice the effects on offspring of feeding their mothers a high-fat (HF) or standard chow (C) diet from weaning through pregnancy and lactation, and whether there are additive phenotypic effects of feeding the offspring an HF diet from weaning to adulthood (dam–offspring dietary group HF-HF). This group was compared with offspring from HF-fed dams fed a C diet from weaning to adulthood (HF-C) and offspring from C-fed mothers fed the C or HF diet (C-C and HF-C, respectively). HF-HF, HF-C and C-HF adult female offspring were heavier, fatter, and had raised serum cholesterol and blood pressure compared with C-C female offspring. We observed a similar trend in male offspring except for the HF-C group which was not heavier or fatter than male C-C offspring. Histology showed lipid vacuoles within hepatocytes in the HF-HF, HF-C and C-HF but not the CC offspring. Serum C-reactive protein was elevated in female (C-HF and HF-HF) but not in male offspring. Elevated blood pressure in the HF-C and C-HF groups was attenuated in the HF-HF group in males but not in females. These findings indicate that long-term consumption of an HF diet by the mother predisposes her offspring to developing a metabolic syndrome-like phenotype in adult life, although cardiovascular effects of an HF diet are related to sex specificity in the HF-HF group
Hypertension, Pregnancy, Diet, Obesity, Metabolic syndrome
514-519
Elahi, Maqsood M.
d9e6af62-c674-4edf-99cc-cc24f50d8e5c
Cagampang, Felino R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Mukhtar, Dhea
4a16db08-521a-4359-9991-b345570f281c
Anthony, Frederick W.
28a46159-500c-48fe-8c55-ef57e034cbeb
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
2009
Elahi, Maqsood M.
d9e6af62-c674-4edf-99cc-cc24f50d8e5c
Cagampang, Felino R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Mukhtar, Dhea
4a16db08-521a-4359-9991-b345570f281c
Anthony, Frederick W.
28a46159-500c-48fe-8c55-ef57e034cbeb
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Elahi, Maqsood M., Cagampang, Felino R., Mukhtar, Dhea, Anthony, Frederick W., Ohri, Sunil K. and Hanson, Mark A.
(2009)
Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice.
British Journal of Nutrition, 102 (4), .
(doi:10.1017/S000711450820749X).
Abstract
In rodents, adverse prenatal nutrition, such as a maternal diet rich in fat during pregnancy, enhances susceptibility of the offspring to hypertension, type 2 diabetes and other features of the human metabolic syndrome in adulthood. However, previous experimental studies were confined to short-term modifications of the maternal diet during pregnancy and/or lactation periods, a situation uncommon in humans. Moreover in humans, the offspring may also consume a high-fat diet, which may take them beyond the range to which their development has adapted them to respond healthily. We examined in C57 mice the effects on offspring of feeding their mothers a high-fat (HF) or standard chow (C) diet from weaning through pregnancy and lactation, and whether there are additive phenotypic effects of feeding the offspring an HF diet from weaning to adulthood (dam–offspring dietary group HF-HF). This group was compared with offspring from HF-fed dams fed a C diet from weaning to adulthood (HF-C) and offspring from C-fed mothers fed the C or HF diet (C-C and HF-C, respectively). HF-HF, HF-C and C-HF adult female offspring were heavier, fatter, and had raised serum cholesterol and blood pressure compared with C-C female offspring. We observed a similar trend in male offspring except for the HF-C group which was not heavier or fatter than male C-C offspring. Histology showed lipid vacuoles within hepatocytes in the HF-HF, HF-C and C-HF but not the CC offspring. Serum C-reactive protein was elevated in female (C-HF and HF-HF) but not in male offspring. Elevated blood pressure in the HF-C and C-HF groups was attenuated in the HF-HF group in males but not in females. These findings indicate that long-term consumption of an HF diet by the mother predisposes her offspring to developing a metabolic syndrome-like phenotype in adult life, although cardiovascular effects of an HF diet are related to sex specificity in the HF-HF group
This record has no associated files available for download.
More information
Published date: 2009
Keywords:
Hypertension, Pregnancy, Diet, Obesity, Metabolic syndrome
Organisations:
Dev Origins of Health & Disease
Identifiers
Local EPrints ID: 72605
URI: http://eprints.soton.ac.uk/id/eprint/72605
ISSN: 0007-1145
PURE UUID: 2a58bec0-81e7-46e9-a032-31456bdd2c7e
Catalogue record
Date deposited: 18 Feb 2010
Last modified: 14 Mar 2024 02:47
Export record
Altmetrics
Contributors
Author:
Maqsood M. Elahi
Author:
Dhea Mukhtar
Author:
Frederick W. Anthony
Author:
Sunil K. Ohri
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics