Maternal high-fat diet: effects on offspring bone structure
Maternal high-fat diet: effects on offspring bone structure
Peak bone mass is believed to partly be programmed in utero. Mouse dams and offspring were given a high-fat diet and offspring studied as adults. Female offspring from high-fat dams exhibited altered trabecular structure indicative of in utero programming. In utero nutrition has consequences in later life.
INTRODUCTION: Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that development of optimal peak bone mass has, in part, a foetal origin and investigated this using a mouse model of maternal dietary fat excess.
METHODS: Offspring from mouse dams fed either standard chow (C) or lifetime high-fat diet (HF) were maintained on a HF diet to adulthood. Femur samples were taken at 30 weeks of age and bone structure, adiposity and strength analysed. Sample sizes were four to six for each sex and each diet group.
RESULTS: Offspring from HF-fed dams showed increased adiposity in the femur in comparison to offspring from C-fed dams. Female offspring from HF dams exhibited altered trabecular structure indicative of in utero programming.
CONCLUSIONS: A maternal HF diet during pregnancy increases bone marrow adiposity and alters bone structure in their offspring.
in utero, micro-computed tomography, programming, structure
1703-1714
Lanham, S.A.
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Roberts, C.
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Hollingsworth, T.
b678269a-e584-43d0-b2a2-8887d674b27b
Sreekumar, R.
057a5adf-52f1-4893-bfc3-f858d83f676f
Elahi, M.
81d409b5-2b3a-4224-b3f4-827c1eee92ee
Cagampang, F.R.
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Hanson, Mark A.
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Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
October 2010
Lanham, S.A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Roberts, C.
b1dc377a-04e8-4757-9e1c-faaf8361ed7a
Hollingsworth, T.
b678269a-e584-43d0-b2a2-8887d674b27b
Sreekumar, R.
057a5adf-52f1-4893-bfc3-f858d83f676f
Elahi, M.
81d409b5-2b3a-4224-b3f4-827c1eee92ee
Cagampang, F.R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Lanham, S.A., Roberts, C., Hollingsworth, T., Sreekumar, R., Elahi, M., Cagampang, F.R., Hanson, Mark A. and Oreffo, Richard O.C.
(2010)
Maternal high-fat diet: effects on offspring bone structure.
Osteoporosis International, 21 (10), .
(doi:10.1007/s00198-009-1118-4).
Abstract
Peak bone mass is believed to partly be programmed in utero. Mouse dams and offspring were given a high-fat diet and offspring studied as adults. Female offspring from high-fat dams exhibited altered trabecular structure indicative of in utero programming. In utero nutrition has consequences in later life.
INTRODUCTION: Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that development of optimal peak bone mass has, in part, a foetal origin and investigated this using a mouse model of maternal dietary fat excess.
METHODS: Offspring from mouse dams fed either standard chow (C) or lifetime high-fat diet (HF) were maintained on a HF diet to adulthood. Femur samples were taken at 30 weeks of age and bone structure, adiposity and strength analysed. Sample sizes were four to six for each sex and each diet group.
RESULTS: Offspring from HF-fed dams showed increased adiposity in the femur in comparison to offspring from C-fed dams. Female offspring from HF dams exhibited altered trabecular structure indicative of in utero programming.
CONCLUSIONS: A maternal HF diet during pregnancy increases bone marrow adiposity and alters bone structure in their offspring.
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Published date: October 2010
Keywords:
in utero, micro-computed tomography, programming, structure
Organisations:
Human Development & Health
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Local EPrints ID: 72617
URI: http://eprints.soton.ac.uk/id/eprint/72617
ISSN: 0937-941X
PURE UUID: 469de0fb-be4b-4686-91dd-899e3afe9fff
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Date deposited: 18 Feb 2010
Last modified: 14 Mar 2024 02:47
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Author:
S.A. Lanham
Author:
C. Roberts
Author:
T. Hollingsworth
Author:
R. Sreekumar
Author:
M. Elahi
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