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Maternal high-fat diet: effects on offspring bone structure

Lanham, S.A., Roberts, C., Hollingsworth, T., Sreekumar, R., Elahi, M., Cagampang, F.R., Hanson, Mark A. and Oreffo, Richard O.C. (2010) Maternal high-fat diet: effects on offspring bone structure Osteoporosis International, 21, (10), pp. 1703-1714. (doi:10.1007/s00198-009-1118-4).

Record type: Article


Peak bone mass is believed to partly be programmed in utero. Mouse dams and offspring were given a high-fat diet and offspring studied as adults. Female offspring from high-fat dams exhibited altered trabecular structure indicative of in utero programming. In utero nutrition has consequences in later life.

INTRODUCTION: Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that development of optimal peak bone mass has, in part, a foetal origin and investigated this using a mouse model of maternal dietary fat excess.

METHODS: Offspring from mouse dams fed either standard chow (C) or lifetime high-fat diet (HF) were maintained on a HF diet to adulthood. Femur samples were taken at 30 weeks of age and bone structure, adiposity and strength analysed. Sample sizes were four to six for each sex and each diet group.

RESULTS: Offspring from HF-fed dams showed increased adiposity in the femur in comparison to offspring from C-fed dams. Female offspring from HF dams exhibited altered trabecular structure indicative of in utero programming.

CONCLUSIONS: A maternal HF diet during pregnancy increases bone marrow adiposity and alters bone structure in their offspring.

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More information

Published date: October 2010
Keywords: in utero, micro-computed tomography, programming, structure
Organisations: Human Development & Health


Local EPrints ID: 72617
ISSN: 0937-941X
PURE UUID: 469de0fb-be4b-4686-91dd-899e3afe9fff
ORCID for S.A. Lanham: ORCID iD
ORCID for Richard O.C. Oreffo: ORCID iD

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Date deposited: 18 Feb 2010
Last modified: 18 Jul 2017 23:53

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Author: S.A. Lanham ORCID iD
Author: C. Roberts
Author: T. Hollingsworth
Author: R. Sreekumar
Author: M. Elahi
Author: F.R. Cagampang
Author: Mark A. Hanson

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