The University of Southampton
University of Southampton Institutional Repository

Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia

May, C., Williams, O., Milner, A.D., Peacock, J., Rafferty, G.F., Hannam, S. and Greenough, A. (2009) Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia Archives of Disease in Childhood - Fetal and Neonatal Edition, 94, (3), F205-F209. (doi:10.1136/adc.2008.146589).

Record type: Article


Objective: To test the hypothesis that exhaled nitric oxide levels on day 28 and changes in exhaled nitric oxide levels in the neonatal period would differ according to whether infants developed bronchopulmonary dysplasia (BPD) and its severity.

Design: Prospective observational study.

Setting: Tertiary neonatal intensive care unit.

Patients: 80 infants (median gestational age 28, range 24–32 weeks), 46 of whom developed BPD.

Interventions: Exhaled nitric oxide measurements were attempted on days 3, 5, 7, 14, 21 and 28.

Main outcome measures: BPD (oxygen dependency at 28 days), mild BPD (oxygen dependent at 28 days, but not 36 weeks postmenstrual age (PMA)); moderate BPD (oxygen dependent at 36 weeks PMA) and severe BPD (respiratory support dependent at 36 weeks PMA).

Results: On day 28, exhaled nitric oxide levels were higher in infants with BPD compared to those without BPD (p<0.001) and there was a linear trend in exhaled nitric oxide results as BPD severity increased (p?=?0.006). No significances in the change in exhaled nitric oxide levels over the neonatal period were found between the four groups.

Conclusion: Exhaled nitric oxide levels are raised in infants with established BPD, particularly in those developing moderate or severe BPD, and may reflect ongoing inflammation.

Full text not available from this repository.

More information

Submitted date: August 2008
Published date: May 2009


Local EPrints ID: 72621
ISSN: 1359-2998
PURE UUID: 5c145712-b7e8-4209-bc48-c27cafb779d7
ORCID for C. May: ORCID iD

Catalogue record

Date deposited: 23 Feb 2010
Last modified: 18 Jul 2017 23:53

Export record



Author: C. May ORCID iD
Author: O. Williams
Author: A.D. Milner
Author: J. Peacock
Author: G.F. Rafferty
Author: S. Hannam
Author: A. Greenough

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.