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Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy

Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy
Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy
There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.
0887-6924
649-652
An, Q.
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Burke, G.A.A.
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Dainton, M.
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Harrison, C.J.
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Kempski, H.
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Konn, Z.
525b4648-7c88-488a-aefa-0018ac485eb4
Myooren, W.
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Stewart, A.
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Taj, M.
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Webb, D.
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Strefford, J.C.
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Martineau, M.
812d24f4-7585-4467-892b-0acf3f429d3e
An, Q.
2f48a7b6-e083-47c6-a1e6-ccbd973318d7
Burke, G.A.A.
9ca20f00-05f7-4b2a-bb2c-5a4a310755ca
Dainton, M.
b0e1e442-49d5-4963-a33e-734fb9053426
Harrison, C.J.
9c9f6b47-8bfc-49dd-b156-74539b170291
Kempski, H.
2f33eaf8-2e77-4d75-8ff8-09796e122797
Konn, Z.
525b4648-7c88-488a-aefa-0018ac485eb4
Myooren, W.
ddac2e34-d18c-4348-a7bd-493293c1aef8
Stewart, A.
42c91dff-7701-4df5-83a9-92e9c1084505
Taj, M.
0f02bfac-e108-42c5-9cb4-f9950b01874a
Webb, D.
711bb5db-23df-4fad-930a-a43ba5439f92
Strefford, J.C.
f4c7fe25-5a30-45c1-9e39-9d6c5b18ed40
Martineau, M.
812d24f4-7585-4467-892b-0acf3f429d3e

An, Q., Burke, G.A.A., Dainton, M., Harrison, C.J., Kempski, H., Konn, Z., Myooren, W., Stewart, A., Taj, M., Webb, D., Strefford, J.C. and Martineau, M. (2010) Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy. Leukemia, 24, 649-652. (doi:10.1038/leu.2009.238).

Record type: Article

Abstract

There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.

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Published date: March 2010
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 72673
URI: https://eprints.soton.ac.uk/id/eprint/72673
ISSN: 0887-6924
PURE UUID: 55dda1a1-679a-49d4-bcc3-91deaa3c77f0

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Date deposited: 22 Feb 2010
Last modified: 19 Jul 2019 23:42

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Contributors

Author: Q. An
Author: G.A.A. Burke
Author: M. Dainton
Author: C.J. Harrison
Author: H. Kempski
Author: Z. Konn
Author: W. Myooren
Author: A. Stewart
Author: M. Taj
Author: D. Webb
Author: J.C. Strefford
Author: M. Martineau

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