Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy
Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy
There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.
649-652
An, Q.
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Burke, G.A.A.
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Dainton, M.
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Harrison, C.J.
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Kempski, H.
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Konn, Z.
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Myooren, W.
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Stewart, A.
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Taj, M.
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Webb, D.
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Strefford, J.C.
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Martineau, M.
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March 2010
An, Q.
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Burke, G.A.A.
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Dainton, M.
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Harrison, C.J.
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Kempski, H.
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Konn, Z.
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Myooren, W.
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Stewart, A.
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Taj, M.
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Webb, D.
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Strefford, J.C.
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Martineau, M.
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An, Q., Burke, G.A.A., Dainton, M., Harrison, C.J., Kempski, H., Konn, Z., Myooren, W., Stewart, A., Taj, M., Webb, D., Strefford, J.C. and Martineau, M.
(2010)
Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy.
Leukemia, 24, .
(doi:10.1038/leu.2009.238).
Abstract
There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.
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Published date: March 2010
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 72673
URI: http://eprints.soton.ac.uk/id/eprint/72673
ISSN: 0887-6924
PURE UUID: 55dda1a1-679a-49d4-bcc3-91deaa3c77f0
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Date deposited: 22 Feb 2010
Last modified: 13 Mar 2024 21:38
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Contributors
Author:
Q. An
Author:
G.A.A. Burke
Author:
M. Dainton
Author:
C.J. Harrison
Author:
H. Kempski
Author:
Z. Konn
Author:
W. Myooren
Author:
A. Stewart
Author:
M. Taj
Author:
D. Webb
Author:
J.C. Strefford
Author:
M. Martineau
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