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Letter. Variant IRF4|[sol]|MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia

Letter. Variant IRF4|[sol]|MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia
Letter. Variant IRF4|[sol]|MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia
A low penetrance risk allele (defined by rs872071) for chronic lymphocytic leukaemia (CLL) has been identified at the interferon regulatory factor 4 (IRF4)|[sol]|multiple myeloma oncogene (MUM1) locus at 6p25.3.1 Given a putative role for IRF4 in the aetiology of CLL and a role in regulating B-cell development, we hypothesised that genetic variation in this gene also has a role in determining prognosis in CLL.
0887-6924
Allan, J.M.
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Bailey, J.R.
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Pettitt, A.R.
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Harris, R.J.
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Pepper, C
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Fegan, C
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Houlston, R.S.
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Sunter, N.J.
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Hall, A.G.
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Butt, J.C.
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Mainou-Fowler, T
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Jackson, G
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Summerfield, G
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Evans, P
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Strefford, J.C.
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Oscier, D.G.
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Pratt, G
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Allsup, D.J.
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Allan, J.M.
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Bailey, J.R.
b809431e-21b6-48d1-a784-e9e91a83b5d0
Pettitt, A.R.
2419c472-6d6f-4e71-ac40-d381e78cb7b0
Harris, R.J.
93202914-3dac-41bd-92e1-f350a43f6dd7
Pepper, C
89924053-411c-4b68-a288-74756b438143
Fegan, C
16cd52f9-5a80-4713-8484-dc81f9ace02c
Houlston, R.S.
513f47bc-c527-47d5-847d-20482ab5d583
Sunter, N.J.
68d859c3-7779-4c9e-b613-d82ff671b614
Hall, A.G.
60608381-ee01-43f9-a279-d99daed49929
Butt, J.C.
eb19df6c-99cb-4862-a249-9f76bb502a74
Mainou-Fowler, T
783680f8-ff2b-4c84-83af-3f4bdd9583fa
Jackson, G
301d4f4d-5538-4d4b-930a-0bc636791bc0
Summerfield, G
714394b7-c6e8-4190-a4d0-db7e3d3478c6
Evans, P
71e2385c-47fa-44f5-9ef4-3d262cf45059
Strefford, J.C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Oscier, D.G.
c2620a1d-25bb-48f7-9651-f5d023636381
Pratt, G
8b475d42-a5ca-43c3-a7a7-67a532d79313
Allsup, D.J.
e297649d-8c9f-474d-a58c-cb392f9504a3

Allan, J.M., Bailey, J.R., Pettitt, A.R., Harris, R.J., Pepper, C, Fegan, C, Houlston, R.S., Sunter, N.J., Hall, A.G., Butt, J.C., Mainou-Fowler, T, Jackson, G, Summerfield, G, Evans, P, Strefford, J.C., Oscier, D.G., Pratt, G and Allsup, D.J. (2010) Letter. Variant IRF4|[sol]|MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia. Leukemia. (doi:10.1038/leu.2009.298).

Record type: Article

Abstract

A low penetrance risk allele (defined by rs872071) for chronic lymphocytic leukaemia (CLL) has been identified at the interferon regulatory factor 4 (IRF4)|[sol]|multiple myeloma oncogene (MUM1) locus at 6p25.3.1 Given a putative role for IRF4 in the aetiology of CLL and a role in regulating B-cell development, we hypothesised that genetic variation in this gene also has a role in determining prognosis in CLL.

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Published date: 21 January 2010
Organisations: Medicine

Identifiers

Local EPrints ID: 72675
URI: https://eprints.soton.ac.uk/id/eprint/72675
ISSN: 0887-6924
PURE UUID: 74f2648b-42e3-4d97-bccf-09c01c2930e8
ORCID for J.C. Strefford: ORCID iD orcid.org/0000-0002-0972-2881

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Date deposited: 02 Mar 2010
Last modified: 20 Jul 2019 00:57

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Contributors

Author: J.M. Allan
Author: J.R. Bailey
Author: A.R. Pettitt
Author: R.J. Harris
Author: C Pepper
Author: C Fegan
Author: R.S. Houlston
Author: N.J. Sunter
Author: A.G. Hall
Author: J.C. Butt
Author: T Mainou-Fowler
Author: G Jackson
Author: G Summerfield
Author: P Evans
Author: J.C. Strefford ORCID iD
Author: D.G. Oscier
Author: G Pratt
Author: D.J. Allsup

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